All Phenotypes Ror2<tm1.1Meg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ror2^tm1.1Meg
targeted mutation 1.1, Michael E Greenberg
MGI:5315485

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pgr^tm2(cre)Lyd/Pgr⁺ Ror1^tm1.1Meg/Ror1^tm1.1Meg Ror2^tm1.1Meg/Ror2^tm1.1Meg	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:5901907
cn2	Ror1^tm1.1Meg/Ror1^tm1.1Meg Ror2^tm1.1Meg/Ror2^tm1.1Meg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S4/SvJae * C57BL/6J * CBA/J	MGI:5315491

Allelic Composition	Pgr^tm2(cre)Lyd/Pgr⁺ Ror1^tm1.1Meg/Ror1^tm1.1Meg Ror2^tm1.1Meg/Ror2^tm1.1Meg
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgr^tm2(cre)Lyd mutation (0 available); any Pgr mutation (75 available)
Ror1^tm1.1Meg mutation (1 available); any Ror1 mutation (58 available)
Ror2^tm1.1Meg mutation (1 available); any Ror2 mutation (125 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal maternal decidual layer morphology ( J:233595 )

• abnormal primary decidual zone (PDZ) development at 6 dpc

• PDZ was absent in some implantation sites with the embryo entrapped within the intact epithelium at 6 dpc

abnormal embryo attachment ( J:233595 )

• uteri either failed to show or had very weak endometrial vascular permeability at the site of blastocyst attachment at 5 dpc

• unattached blastocysts were recovered from uteri at 5 dpc

• defects in crypt formation

• some blastocysts situated within the primary lumen

reduced female fertility ( J:233595 )

• only 29% of plug-positive females produce a (small) litter

• high resorption rates on 12 dpc

decreased litter size ( J:233595 )

• in the few fertile mice

embryo

abnormal maternal decidual layer morphology ( J:233595 )

• abnormal primary decidual zone (PDZ) development at 6 dpc

• PDZ was absent in some implantation sites with the embryo entrapped within the intact epithelium at 6 dpc

Allelic Composition	Ror1^tm1.1Meg/Ror1^tm1.1Meg Ror2^tm1.1Meg/Ror2^tm1.1Meg H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Ror1^tm1.1Meg mutation (1 available); any Ror1 mutation (58 available)
Ror2^tm1.1Meg mutation (1 available); any Ror2 mutation (125 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Ror1^tm1.1Meg/Ror1^tm1.1Meg Ror2^tm1.1Meg/Ror2^tm1.1Meg H2az2^{Tg(Wnt1-cre)11Rth}/0 embryos exhibit sympathetic axon branching defects

nervous system

abnormal sympathetic neuron innervation pattern ( J:182150 )

• sympathetic innervation defects are seen in several target organs at E17.5

• defects are similar to those in Wnt5a null mice

• however, sympathetic chain ganglia appear grossly intact

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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