Phenotypes associated with this allele

• Allele Symbol: Catsperd^tm1.1Clph
• Allele Name: targeted mutation 1.1, David E Clapham
• Allele ID: MGI:5315769
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Catsperd^tm1.1Clph/Catsperd^tm1.1Clph	involves: 129S4/SvJae * C57BL/6	MGI:5315771

Genotype
MGI:5315771

hm1

• Allelic Composition: Catsperd^tm1.1Clph/Catsperd^tm1.1Clph
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal germ cell morphology ( J:182472 )

oligozoospermia ( J:182472 )

♂ • sperm count slightly lower at 2-3 months of age but normal at 7-8 months

teratozoospermia ( J:182472 )

♂ • bend angle between the head/midpiece and principal piece is substantially reduced in capacitated sperm

abnormal reproductive system physiology ( J:182472 )

decreased hyperactivated sperm motility ( J:182472 )

♂ • bicarbonate-evoked activation of sperm is normal

♂ • hyperactivated motility fails to develop

♂ • flagellar amplitudes are substantially lower than for capacitated heterozygote sperm

male infertility ( J:182472 )

♂ • no litters are produced when males are mated to wild-type or heterozygous females

cellular

abnormal germ cell morphology ( J:182472 )

oligozoospermia ( J:182472 )

♂ • sperm count slightly lower at 2-3 months of age but normal at 7-8 months

teratozoospermia ( J:182472 )

♂ • bend angle between the head/midpiece and principal piece is substantially reduced in capacitated sperm

decreased hyperactivated sperm motility ( J:182472 )

♂ • bicarbonate-evoked activation of sperm is normal

♂ • hyperactivated motility fails to develop

♂ • flagellar amplitudes are substantially lower than for capacitated heterozygote sperm