cellular
azoospermia
(
J:34742
)
|
• testes and epididimi are entirely devoid of sperm
|
|
• numbers of Sertoli cells, interstitial cells and spermatogonia are normal to the primary spermatocyte stage
• from the primary spermatocyte stage onward, very few or no cells are present, indicating arrest of spermatogenesis at some point during meiosis
|
mortality/aging
N |
• balanced translocation bearing dams produce sterile and fertile male progeny (based on testis size) at a 1:1 ratio; thus, the small litters are not due to embryonic death of balanced carriers
|
reproductive system
azoospermia
(
J:34742
)
|
• testes and epididimi are entirely devoid of sperm
|
|
• numbers of Sertoli cells, interstitial cells and spermatogonia are normal to the primary spermatocyte stage
• from the primary spermatocyte stage onward, very few or no cells are present, indicating arrest of spermatogenesis at some point during meiosis
|
|
• male mice balanced for this translocation have small testes (< 50 mg)
|
|
• female mice balanced for this translocation produce litters ~52% as large as those of dams with a normal karyotype (average litter sizes 4.12 (based on 150 litters from 27 females) vs. 7.91 (among 53 litters from 35 females), respectively)
|
• mean litter size of dams balanced for this translocation is ~52% that of dams with a normal karyotype (average litter sizes 4.12 (based on 150 litters from 27 females) vs. 7.91 (among 53 litters from 35 females), respectively)
|
|
• males balanced for this translocation are sterile
|
endocrine/exocrine glands
|
• male mice balanced for this translocation have small testes (< 50 mg)
|