Analysis Tools
cellular
azoospermia
(
J:34742
)
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• testes and epididimi are entirely devoid of sperm
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• numbers of Sertoli cells, interstitial cells and spermatogonia are normal to the primary spermatocyte stage
• from the primary spermatocyte stage onward, very few or no cells are present, indicating arrest of spermatogenesis at some point during meiosis
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mortality/aging
| N |
• balanced translocation bearing dams produce sterile and fertile male progeny (based on testis size) at a 1:1 ratio; thus, the small litters are not due to embryonic death of balanced carriers
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reproductive system
azoospermia
(
J:34742
)
|
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• testes and epididimi are entirely devoid of sperm
|
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• numbers of Sertoli cells, interstitial cells and spermatogonia are normal to the primary spermatocyte stage
• from the primary spermatocyte stage onward, very few or no cells are present, indicating arrest of spermatogenesis at some point during meiosis
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• male mice balanced for this translocation have small testes (< 50 mg)
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• female mice balanced for this translocation produce litters ~52% as large as those of dams with a normal karyotype (average litter sizes 4.12 (based on 150 litters from 27 females) vs. 7.91 (among 53 litters from 35 females), respectively)
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• mean litter size of dams balanced for this translocation is ~52% that of dams with a normal karyotype (average litter sizes 4.12 (based on 150 litters from 27 females) vs. 7.91 (among 53 litters from 35 females), respectively)
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• males balanced for this translocation are sterile
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endocrine/exocrine glands
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• male mice balanced for this translocation have small testes (< 50 mg)
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