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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cfl2tm1Itl
targeted mutation 1, inGenious Targeting Laboratory
MGI:5316051
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cfl2tm1Itl/Cfl2tm1Itl
Tg(Ckmm-cre)5Khn/0 		involves: C57BL/6 * C57BL/6NTac * FVB/N MGI:5316089
cn2
 		Cfl2tm1Itl/Cfl2tm1Itl
Tg(ACTA1-cre)79Jme/0 		involves: C57BL/6J * C57BL/6NTac * SJL MGI:5316090
cn3
 		Cfl2tm1Itl/Cfl2tm1Itl
Tg(Mef2c-cre)1Blk/0 		involves: C57BL/6NTac MGI:5316091


Genotype
MGI:5316089
cn1
Allelic
Composition		 Cfl2tm1Itl/Cfl2tm1Itl
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfl2tm1Itl mutation (1 available); any Cfl2 mutation (19 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:182571 )
• mice live for 16 to 33 days
postnatal lethality, incomplete penetrance ( J:182571 )
• mice live for 16 to 33 days

muscle
abnormal skeletal muscle morphology ( J:182571 )
• accumulation of F-actin
skeletal muscle fiber degeneration ( J:182571 )
• at P21, mice exhibit ballooning degeneration interspersed with normal-looking myofibers and pale core-like areas consistent with myofibrillar disruption and absent mitochondria unlike in wild-type mice

growth/size/body
decreased body size ( J:182571 )
decreased body weight ( J:182571 )
• 2- to 4-fold between P8 and P31




Genotype
MGI:5316090
cn2
Allelic
Composition		 Cfl2tm1Itl/Cfl2tm1Itl
Tg(ACTA1-cre)79Jme/0
Genetic
Background		 involves: C57BL/6J * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfl2tm1Itl mutation (1 available); any Cfl2 mutation (19 available)
Tg(ACTA1-cre)79Jme mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:182571 )
• mice die between P7 and P12

muscle
abnormal sarcomere morphology ( J:182571 )
• muscle fibers exhibit intact sarcomeres alongside disrupted ones unlike in wild-type mice
abnormal skeletal muscle morphology ( J:182571 )
• accumulation of F-actin
abnormal skeletal muscle fiber morphology ( J:182571 )
• muscle fibers exhibit intact sarcomeres alongside disrupted ones unlike in wild-type mice




Genotype
MGI:5316091
cn3
Allelic
Composition		 Cfl2tm1Itl/Cfl2tm1Itl
Tg(Mef2c-cre)1Blk/0
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfl2tm1Itl mutation (1 available); any Cfl2 mutation (19 available)
Tg(Mef2c-cre)1Blk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:182571 )
• mice die between P7 and P12

muscle
abnormal skeletal muscle morphology ( J:182571 )
• accumulation of F-actin




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory