About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cfl2tm1Itl
targeted mutation 1, inGenious Targeting Laboratory
MGI:5316051
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cfl2tm1Itl/Cfl2tm1Itl
Tg(Ckmm-cre)5Khn/0 		involves: C57BL/6 * C57BL/6NTac * FVB/N MGI:5316089
cn2
 		Cfl2tm1Itl/Cfl2tm1Itl
Tg(ACTA1-cre)79Jme/0 		involves: C57BL/6J * C57BL/6NTac * SJL MGI:5316090
cn3
 		Cfl2tm1Itl/Cfl2tm1Itl
Tg(Mef2c-cre)1Blk/0 		involves: C57BL/6NTac MGI:5316091


Genotype
MGI:5316089
cn1
Allelic
Composition		 Cfl2tm1Itl/Cfl2tm1Itl
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfl2tm1Itl mutation (1 available); any Cfl2 mutation (19 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:182571 )
• mice live for 16 to 33 days
postnatal lethality, incomplete penetrance ( J:182571 )
• mice live for 16 to 33 days

muscle
abnormal skeletal muscle morphology ( J:182571 )
• accumulation of F-actin
skeletal muscle fiber degeneration ( J:182571 )
• at P21, mice exhibit ballooning degeneration interspersed with normal-looking myofibers and pale core-like areas consistent with myofibrillar disruption and absent mitochondria unlike in wild-type mice

growth/size/body
decreased body size ( J:182571 )
decreased body weight ( J:182571 )
• 2- to 4-fold between P8 and P31




Genotype
MGI:5316090
cn2
Allelic
Composition		 Cfl2tm1Itl/Cfl2tm1Itl
Tg(ACTA1-cre)79Jme/0
Genetic
Background		 involves: C57BL/6J * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfl2tm1Itl mutation (1 available); any Cfl2 mutation (19 available)
Tg(ACTA1-cre)79Jme mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:182571 )
• mice die between P7 and P12

muscle
abnormal sarcomere morphology ( J:182571 )
• muscle fibers exhibit intact sarcomeres alongside disrupted ones unlike in wild-type mice
abnormal skeletal muscle morphology ( J:182571 )
• accumulation of F-actin
abnormal skeletal muscle fiber morphology ( J:182571 )
• muscle fibers exhibit intact sarcomeres alongside disrupted ones unlike in wild-type mice




Genotype
MGI:5316091
cn3
Allelic
Composition		 Cfl2tm1Itl/Cfl2tm1Itl
Tg(Mef2c-cre)1Blk/0
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfl2tm1Itl mutation (1 available); any Cfl2 mutation (19 available)
Tg(Mef2c-cre)1Blk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:182571 )
• mice die between P7 and P12

muscle
abnormal skeletal muscle morphology ( J:182571 )
• accumulation of F-actin




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory