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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh
targeted mutation 1.1, Farhad R Danesh
MGI:5316078
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh/Gt(ROSA)26Sor+
Tg(NPHS2-icre/ERT2)1Dnsh/0 		involves: C57BL/6 MGI:5316081


Genotype
MGI:5316081
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh/Gt(ROSA)26Sor+
Tg(NPHS2-icre/ERT2)1Dnsh/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(NPHS2-icre/ERT2)1Dnsh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
albuminuria ( J:182287 )
• following 2 and 5 weeks of tamoxifen treatment
abnormal podocyte foot process morphology ( J:182287 )
• tamoxifen-treated mice exhibit reduced numbers of podocytes compared with wild-type mice
podocyte foot process effacement ( J:182287 )
• tamoxifen-treated mice exhibit reduced numbers of podocytes compared with wild-type mice
expanded mesangial matrix ( J:182287 )
• in some mice 5 weeks after induction with tamoxifen

homeostasis/metabolism
albuminuria ( J:182287 )
• following 2 and 5 weeks of tamoxifen treatment




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory