Analysis Tools
immune system
| N |
• Th2 differentiation is normal
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• in the lungs of mice infected with S. venezuelensis
• in response to S. venezuelensis, mice exhibit reduced nuocytes in bronchoalveolar lavage fluid compared with wild-type mice
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• in response to S. venezuelensis
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• reduced systemic Th2 response in response to S. venezuelensis
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• in response to S. venezuelensis, mice exhibit reduced serum IgE, modestly impaired ability to expel the nematode, reduced accumulation of eosinophils in the lungs, only a modest eosinophilic inflammation and goblet cell hyperplasia, and reduced nuocytes in bronchoalveolar lavage fluid compared with wild-type mice
• however, treatment with IL33 accelerates worm expulsion
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respiratory system
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• in response to S. venezuelensis, mice exhibit reduced goblet cell hyperplasia compared with wild-type mice
• chitin-treated mice fail to exhibit goblet cell hyperplasia compared with wild-type mice
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hematopoietic system
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• in the lungs of mice infected with S. venezuelensis
• in response to S. venezuelensis, mice exhibit reduced nuocytes in bronchoalveolar lavage fluid compared with wild-type mice
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• in response to S. venezuelensis
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• reduced systemic Th2 response in response to S. venezuelensis
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