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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atmtm2Pmc
targeted mutation 2, Peter J McKinnon
MGI:5316210
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atmtm2Pmc/Atmtm2Pmc
Pnkptm1.1Pmc/Pnkptm1.1Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * C57BL/6 * SJL MGI:5795758
cn2
 		Atmtm2Pmc/Atmtm2Pmc
Atrtm2Bal/Atrtm2Bal
Tg(Nes-cre)1Kln/0 		involves: 129S2/SvPas * C57BL/6 * SJL MGI:5316230
cn3
 		Atmtm2Pmc/Atmtm2Pmc
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S4/SvJaeSor * C57BL/6J MGI:5316229


Genotype
MGI:5795758
cn1
Allelic
Composition		 Atmtm2Pmc/Atmtm2Pmc
Pnkptm1.1Pmc/Pnkptm1.1Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm2Pmc mutation (0 available); any Atm mutation (170 available)
Pnkptm1.1Pmc mutation (0 available); any Pnkp mutation (38 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
intracranial hemorrhage ( J:226703 )
• hemorrhage in the brain

cellular
increased brain apoptosis ( J:226703 )
• apoptosis in the developing cerebellum is similar to single conditional Pnkp mutants

nervous system
intracranial hemorrhage ( J:226703 )
• hemorrhage in the brain
increased brain apoptosis ( J:226703 )
• apoptosis in the developing cerebellum is similar to single conditional Pnkp mutants
abnormal brain interneuron morphology ( J:226703 )
• reduction in cerebellar interneurons




Genotype
MGI:5316230
cn2
Allelic
Composition		 Atmtm2Pmc/Atmtm2Pmc
Atrtm2Bal/Atrtm2Bal
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm2Pmc mutation (0 available); any Atm mutation (170 available)
Atrtm2Bal mutation (1 available); any Atr mutation (133 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron apoptosis ( J:181920 )
• decrease in apoptosis in the external granule layer and ganglionic eminence compared to mutant mice wild-type for Atm
abnormal nervous system morphology ( J:181920 )
• similar neuropathology to mutant mice wild-type for Atm

cellular
decreased cellular sensitivity to ionizing radiation ( J:181920 )
• resistance to radiation induced DNA damage-induced apoptosis in neural tissues
abnormal neuron apoptosis ( J:181920 )
• decrease in apoptosis in the external granule layer and ganglionic eminence compared to mutant mice wild-type for Atm




Genotype
MGI:5316229
cn3
Allelic
Composition		 Atmtm2Pmc/Atmtm2Pmc
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm2Pmc mutation (0 available); any Atm mutation (170 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cellular sensitivity to ionizing radiation ( J:181920 )
• resistance to radiation induced DNA damage-induced apoptosis in neural tissues




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory