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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pum1tm1.2Hfl
targeted mutation 1.1, Haifan Lin
MGI:5316377
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pum1tm1.2Hfl/Pum1tm1.2Hfl involves: 129 * C57BL/6 * FVB MGI:5316382
ht2
 		Pum1tm1.2Hfl/Pum1+ involves: 129 * C57BL/6 * FVB MGI:5316381
cn3
 		Pum1tm1.1Hfl/Pum1tm1.2Hfl
Tg(Ddx4-cre)1Dcas/0 		involves: 129 * C57BL/6 * FVB MGI:5316380
cx4
 		Pum1tm1.2Hfl/Pum1tm1.2Hfl
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * C57BL/6 * FVB MGI:5316383


Genotype
MGI:5316382
hm1
Allelic
Composition		 Pum1tm1.2Hfl/Pum1tm1.2Hfl
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pum1tm1.2Hfl mutation (0 available); any Pum1 mutation (170 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:182280 )
N
• male mice exhibit normal spermiogenesis, cell division and steroidogenesis
increased male germ cell apoptosis ( J:182280 )
• 6.8-fold higher than in control mice
abnormal spermatogenesis ( J:182280 )
• spermatogenesis is compromised with premature release of spermatocytes into the epididymis compared to in control mice

growth/size/body
decreased body weight ( J:182280 )
• at 8 weeks

cellular
increased male germ cell apoptosis ( J:182280 )
• 6.8-fold higher than in control mice

endocrine/exocrine glands




Genotype
MGI:5316381
ht2
Allelic
Composition		 Pum1tm1.2Hfl/Pum1+
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pum1tm1.2Hfl mutation (0 available); any Pum1 mutation (170 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased male germ cell apoptosis ( J:182280 )
• 2.7-fold higher than in control mice

cellular
increased male germ cell apoptosis ( J:182280 )
• 2.7-fold higher than in control mice




Genotype
MGI:5316380
cn3
Allelic
Composition		 Pum1tm1.1Hfl/Pum1tm1.2Hfl
Tg(Ddx4-cre)1Dcas/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pum1tm1.1Hfl mutation (0 available); any Pum1 mutation (170 available)
Pum1tm1.2Hfl mutation (0 available); any Pum1 mutation (170 available)
Tg(Ddx4-cre)1Dcas mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
increased male germ cell apoptosis ( J:182280 )
• 7.5-fold higher than in control mice

cellular
increased male germ cell apoptosis ( J:182280 )
• 7.5-fold higher than in control mice




Genotype
MGI:5316383
cx4
Allelic
Composition		 Pum1tm1.2Hfl/Pum1tm1.2Hfl
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pum1tm1.2Hfl mutation (0 available); any Pum1 mutation (170 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:182280 )
N
• testis hypotrophy and male germ cell apoptosis are rescued
small seminiferous tubules ( J:182280 )
• not as much as in Pum1tm1.2Hfl homozygotes

endocrine/exocrine glands
small seminiferous tubules ( J:182280 )
• not as much as in Pum1tm1.2Hfl homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory