All Phenotypes Pik3c3<tm1c(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pik3c3^{tm1c(EUCOMM)Wtsi}
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5316387

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi}	involves: C57BL/6N	MGI:5427441
cn2	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA	MGI:5427446
cn3	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * C57BL/6N * DBA	MGI:5427443
cn4	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: C57BL/6N * C57BL/6NCrj	MGI:5427442
cn5	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Ckmm-cre)5Khn/0	involves: C57BL/6N * C57BL/6NCrj * FVB/N	MGI:5427445
cn6	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(Ckmm-cre)5Khn/0	involves: C57BL/6N * FVB/N	MGI:5427444

Allelic Composition	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3c3^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Pik3c3 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} MEFs transduced with cre-expressing adenovirus exhibit large translucent vacuoles

cellular

abnormal vacuole morphology ( J:182628 )

• mouse embryonic fibroblasts transduced with a cre-expressing adenovirus exhibit large translucent vacuoles (late endosomes and/or lysosomes) unlike control cells

abnormal autophagy ( J:182628 )

• fed and nutrient-starved conditions mouse embryonic fibroblasts transduced with a cre-expressing adenovirus exhibit blocked autophagy flux unlike control cells

decreased cell proliferation ( J:182628 )

• in mouse embryonic fibroblasts transduced with a cre-expressing adenovirus

homeostasis/metabolism

abnormal autophagy ( J:182628 )

• fed and nutrient-starved conditions mouse embryonic fibroblasts transduced with a cre-expressing adenovirus exhibit blocked autophagy flux unlike control cells

Allelic Composition	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3c3^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Pik3c3 mutation (47 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal liver physiology ( J:182628 )

• livers from fed and starved exhibit blocked autophagy flux compared with control livers

cellular

abnormal autophagy ( J:182628 )

• livers from fed and starved exhibit blocked autophagy flux compared with control livers

homeostasis/metabolism

abnormal autophagy ( J:182628 )

• livers from fed and starved exhibit blocked autophagy flux compared with control livers

Allelic Composition	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: C57BL/6 * C57BL/6N * DBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Liver steatosis in Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice

mortality/aging

premature death ( J:182628 )

• most mice die within 1 year

liver/biliary system

abnormal liver morphology ( J:182628 )

• mice exhibit intracellular vacuolation and accumulation of lipids unlike in control mice

• fed mice exhibit a large number of small-sized mitochondria unlike control mice

• livers of fasted mice exhibit virtually no autophagosomes and many swollen mitochondria unlike livers from control mice

• livers exhibit increased protein content compared with wild-type livers

enlarged liver ( J:182628 )

decreased liver glycogen level ( J:182628 )

hepatic steatosis ( J:182628 )

pale liver ( J:182628 )

homeostasis/metabolism

decreased liver glycogen level ( J:182628 )

growth/size/body

decreased body size ( J:182628 )

enlarged liver ( J:182628 )

Allelic Composition	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background	involves: C57BL/6N * C57BL/6NCrj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3c3^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Pik3c3 mutation (47 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal autophagy ( J:182628 )

• fed and nutrient-starved conditions mouse embryonic fibroblasts transduced with a cre-expressing adenovirus exhibit blocked autophagy flux unlike control cells

homeostasis/metabolism

abnormal autophagy ( J:182628 )

• fed and nutrient-starved conditions mouse embryonic fibroblasts transduced with a cre-expressing adenovirus exhibit blocked autophagy flux unlike control cells

Allelic Composition	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(CAG-EGFP/Map1lc3b)53Nmz/0 Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: C57BL/6N * C57BL/6NCrj * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardial fiber physiology ( J:182628 )

• hearts from fed and starved exhibit blocked autophagy flux compared with control hearts

cellular

abnormal autophagy ( J:182628 )

• hearts from fed and starved exhibit blocked autophagy flux compared with control hearts

homeostasis/metabolism

abnormal autophagy ( J:182628 )

• hearts from fed and starved exhibit blocked autophagy flux compared with control hearts

Allelic Composition	Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(Ckmm-cre)5Khn/0
Genetic Background	involves: C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3c3^{tm1c(EUCOMM)Wtsi} mutation (1 available); any Pik3c3 mutation (47 available)
Tg(Ckmm-cre)5Khn mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cardiac dysfunction in Pik3c3^{tm1c(EUCOMM)Wtsi}/Pik3c3^{tm1c(EUCOMM)Wtsi} Tg(Ckmm-cre)5Khn/0 mice

mortality/aging

premature death ( J:182628 )

• mice die between 5 and 13 weeks of age

cardiovascular system

abnormal heart morphology ( J:182628 )

• hearts exhibit disorganized mitochondria and Z-lines with increased number of small-sized mitochondria and enlarged vacuoles compared with control hearts

enlarged heart ( J:182628 )

increased heart weight ( J:182628 )

abnormal heart left ventricle morphology ( J:182628 )

• mice exhibit an increased in left ventricular wall thickness and mass compared with control mice

increased heart left ventricle weight ( J:182628 )

decreased cardiac muscle contractility ( J:182628 )

• decreased cardiac contractility with lower ejection fraction and fractional shortening compared with control mice

congestive heart failure ( J:182628 )

muscle

decreased cardiac muscle contractility ( J:182628 )

• decreased cardiac contractility with lower ejection fraction and fractional shortening compared with control mice

growth/size/body

enlarged heart ( J:182628 )

increased heart weight ( J:182628 )

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