All Phenotypes Yap1<tm1.1Fcam> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Yap1^tm1.1Fcam
targeted mutation 1.1, Fernando D Camargo
MGI:5316446

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Yap1^tm1.1Fcam/Yap1^tm1.1Fcam Tg(KRT14-cre)1Amc/0	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:5316466
cn2	Yap1^tm1.1Fcam/Yap1^tm2.1Fcam Tg(KRT14-cre)1Amc/0	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:5316467
cn3	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} Yap1^tm1.1Fcam/Yap1⁺ Tg(Tek-cre)1Ywa/0	involves: 129S4/SvJae * C57BL/6N * CBA * SJL	MGI:6360911

Allelic Composition	Yap1^tm1.1Fcam/Yap1^tm1.1Fcam Tg(KRT14-cre)1Amc/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Amc mutation (2 available)
Yap1^tm1.1Fcam mutation (0 available); any Yap1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

impaired skin barrier function ( J:171057 )

• at E18.5 in limbs, ears, nose, and mouth

abnormal epidermal layer morphology ( J:171057 )

• at E18.5, mice lack epidermal tissue covering the distal part of the limbs, eyes and ears

• disorganized architecture

abnormal epidermis stratum basale morphology ( J:171057 )

• basal cells lose their columnar organization and adopt a flat morphology unlike in control mice

thin epidermis stratum basale ( J:171057 )

• hypoplastic

abnormal epidermis stratum corneum morphology ( J:171057 )

• reduced

thin epidermis ( J:171057 )

abnormal skin condition ( J:171057 )

• fragile at E18.5

thin skin ( J:171057 )

• at E18.5

abnormal epidermal stem cell morphology ( J:171057 )

• mice exhibit a greater than 50-fold decrease in the number of colony-forming cells compared with control mice

cellular

decreased cell proliferation ( J:171057 )

• mice exhibit a greater than 3.5-fold decrease in cell proliferation in limb skin compared with control mice

increased cell proliferation ( J:171057 )

• mice exhibit a more than 3-fold increase in cell proliferation in back skin compared with control mice

homeostasis/metabolism

impaired skin barrier function ( J:171057 )

• at E18.5 in limbs, ears, nose, and mouth

Allelic Composition	Yap1^tm1.1Fcam/Yap1^tm2.1Fcam Tg(KRT14-cre)1Amc/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Amc mutation (2 available)
Yap1^tm1.1Fcam mutation (0 available); any Yap1 mutation (37 available)
Yap1^tm2.1Fcam mutation (0 available); any Yap1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:171057 )

integument

abnormal skin morphology ( J:171057 )

• authors state that mice phenocopy Yap1^tm1.1Fcam/Yap1^tm1.1Fcam Tg(KRT14-cre)1Amc mice

abnormal epidermal layer morphology ( J:171057 )

• at E18.5, mice lack epidermal tissue covering the distal part of the limbs, eyes and ears

thin skin ( J:171057 )

• limb skin

cellular

decreased cell proliferation ( J:171057 )

• mice exhibit reduced proliferation of basal cells in limb skin compared with control mice

Allelic Composition	Vgll4^{tm1b(EUCOMM)Hmgu}/Vgll4^{tm1c(EUCOMM)Hmgu} Yap1^tm1.1Fcam/Yap1⁺ Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S4/SvJae * C57BL/6N * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tek-cre)1Ywa mutation (6 available)
Vgll4^{tm1b(EUCOMM)Hmgu} mutation (1 available); any Vgll4 mutation (24 available)
Vgll4^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Vgll4 mutation (24 available)
Yap1^tm1.1Fcam mutation (0 available); any Yap1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:273437 )

N	• hearts are normal morphology and function with normal valve thickness and cardiomyocyte proliferation and apoptosis rates

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