All Phenotypes Yap1<tm2.1Fcam> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Yap1^tm2.1Fcam
targeted mutation 2.1, Fernando D Camargo
MGI:5316452

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Yap1^tm1.1Fcam/Yap1^tm2.1Fcam Tg(KRT14-cre)1Amc/0	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:5316467

Allelic Composition	Yap1^tm1.1Fcam/Yap1^tm2.1Fcam Tg(KRT14-cre)1Amc/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Amc mutation (2 available)
Yap1^tm1.1Fcam mutation (0 available); any Yap1 mutation (38 available)
Yap1^tm2.1Fcam mutation (0 available); any Yap1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:171057 )

integument

abnormal skin morphology ( J:171057 )

• authors state that mice phenocopy Yap1^tm1.1Fcam/Yap1^tm1.1Fcam Tg(KRT14-cre)1Amc mice

abnormal epidermal layer morphology ( J:171057 )

• at E18.5, mice lack epidermal tissue covering the distal part of the limbs, eyes and ears

thin skin ( J:171057 )

• limb skin

cellular

decreased cell proliferation ( J:171057 )

• mice exhibit reduced proliferation of basal cells in limb skin compared with control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24