Phenotypes associated with this allele

• Allele Symbol: Tg(PAX6)77Ndha
• Allele Name: transgene insertion 77, Nicholas Hastie
• Allele ID: MGI:5316840
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mitf^tm3.1Arnh/Mitf^tm3.1Arnh Tg(PAX6)77Ndha/?	involves: 129S6/SvEvTac * C57BL/6N * CBA	MGI:5316884
cx2	Pax6^Sey/Pax6^Sey Tg(PAX6)77Ndha/?	involves: C57BL/6 * CBA	MGI:5316843
cx3	Mitf^mi-vga9/Mitf^mi-vga9 Tg(PAX6)77Ndha/Tg(PAX6)77Ndha	involves: C57BL/6 * CBA	MGI:5316881
tg4	Tg(PAX6)77Ndha/Tg(PAX6)77Ndha	involves: C57BL/6 * CBA	MGI:5316845
tg5	Tg(PAX6)77Ndha/?	involves: C57BL/6 * CBA	MGI:5316844

Genotype
MGI:5316884

cx1

• Allelic Composition: Mitf^tm3.1Arnh/Mitf^tm3.1Arnh; Tg(PAX6)77Ndha/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:188155 )

N • no dorsal thickening of the retinal pigment epithelium observed

Genotype
MGI:5316843

cx2

• Allelic Composition: Pax6^Sey/Pax6^Sey; Tg(PAX6)77Ndha/?
• Genetic Background: involves: C57BL/6 * CBA

vision/eye

vision/eye phenotype ( J:34194 )

N • normal eye size

taste/olfaction

taste/olfaction phenotype ( J:34194 )

N • nasal cavity present

N • normal olfactory epithelium

nervous system

nervous system phenotype ( J:34194 )

N • olfactory bulbs normal

N • subventricular zone of cerebral hemispheres normal

Genotype
MGI:5316881

cx3

• Allelic Composition: Mitf^mi-vga9/Mitf^mi-vga9; Tg(PAX6)77Ndha/Tg(PAX6)77Ndha
• Genetic Background: involves: C57BL/6 * CBA

vision/eye

vision/eye phenotype ( J:188155 )

N • no thickening of the retinal pigment epithelium

Genotype
MGI:5316845

tg4

• Allelic Composition: Tg(PAX6)77Ndha/Tg(PAX6)77Ndha
• Genetic Background: involves: C57BL/6 * CBA

vision/eye

vision/eye phenotype ( J:188155 )

N • no thickening of the retinal pigment epithelium

abnormal lens morphology ( J:137605 )

• lens defects do not appear until after E12.5

• retinal attachment to the lens develops as the vitreous disappears

microphthalmia ( J:137605 )

• eyes are significantly smaller by E14.5

abnormal posterior eye segment morphology ( J:137605 )

abnormal optic chiasm morphology ( J:137605 )

• fewer retinal ganglion cell axons reach the optic chiasma

• reduction in contralateral projection of retinal ganglion cell axons

abnormal retina morphology ( J:137605 )

• retinal attachment to the lens develops as the vitreous disappears

• rosette-like structures in the retina at 4 days of age

abnormal retina pigment epithelium morphology ( J:137605 )

• extends along the optic stalk

abnormal retina neuronal layer morphology ( J:137605 )

• extends along the optic stalk

disorganized retina ganglion layer ( J:137605 )

• less structured at E18.5

• retinal ganglion cell axons follow a more erratic course toward the optic nerve

• fewer retinal ganglion cell axons reach the optic chiasma

retina fold ( J:137605 )

• peripheral retina folds back toward the vitreous chamber

abnormal vitreous body morphology ( J:137605 )

• vitreous chamber almost completely disappears by 2 days of age

• hyperplastic vitreous at E14.5

pigmentation

abnormal retina pigment epithelium morphology ( J:137605 )

• extends along the optic stalk

nervous system

abnormal optic chiasm morphology ( J:137605 )

• fewer retinal ganglion cell axons reach the optic chiasma

• reduction in contralateral projection of retinal ganglion cell axons

Genotype
MGI:5316844

tg5

• Allelic Composition: Tg(PAX6)77Ndha/?
• Genetic Background: involves: C57BL/6 * CBA

vision/eye

abnormal anterior eye segment morphology ( J:34194 )

abnormal ciliary body morphology ( J:34194 )

• disorganized in normal sized eyes

abnormal iris morphology ( J:34194 )

• cyst-like structures in the iris of normal sized eyes

abnormal cornea morphology ( J:34194 )

• reduced corneal size

abnormal lens morphology ( J:34194 )

• retinal attachments to the lens

microphthalmia ( J:34194 )

• high percentage of mice with reduced eye size

• microphthalmic eyes highly disorganized

abnormal retina morphology ( J:34194 )

• retinal attachments to the lens