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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Piwil1tm1.1Embrp
targeted mutation 1.1, Ramesh Pillai
MGI:5316870
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Piwil1tm1.1Embrp/Piwil1+ involves: 129S4/SvJaeSor * C57BL/6 MGI:5316873
ht2
 		Piwil1tm1.1Embrp/Piwil1tm1.2Embrp involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 MGI:5316875


Genotype
MGI:5316873
ht1
Allelic
Composition		 Piwil1tm1.1Embrp/Piwil1+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piwil1tm1.1Embrp mutation (1 available); any Piwil1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:182800 )
N
• female mice exhibit normal fertility
azoospermia ( J:182800 )
• mutant sperm degenerate in the epididymis
abnormal spermatid morphology ( J:182800 )
• with abnormal nuclear morphologies

cellular
azoospermia ( J:182800 )
• mutant sperm degenerate in the epididymis
abnormal spermatid morphology ( J:182800 )
• with abnormal nuclear morphologies




Genotype
MGI:5316875
ht2
Allelic
Composition		 Piwil1tm1.1Embrp/Piwil1tm1.2Embrp
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piwil1tm1.1Embrp mutation (1 available); any Piwil1 mutation (28 available)
Piwil1tm1.2Embrp mutation (1 available); any Piwil1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal chromatoid body morphology ( J:182800 )
• accumulation of ribonucleaoprotein granules (chromatoid bodies)
arrest of spermatogenesis ( J:182800 )
• after meiosis at haploid round spermatids

cellular
abnormal chromatoid body morphology ( J:182800 )
• accumulation of ribonucleaoprotein granules (chromatoid bodies)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory