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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Atoh1-sb11)1Mtay
transgene insertion 1, Michel D Taylor
MGI:5316979
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ptch1tm1Mps/Ptch1+
Tg(Atoh1-sb11)1Mtay/0
TgTn(sb-T2/Onc3)12740Njen/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J * ICR MGI:5317025
cn2
Tg(Atoh1-sb11)1Mtay/0
TgTn(sb-T2/Onc3)12740Njen/0
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * C3H * C57BL/6J * ICR MGI:5317026
cn3
Tg(Atoh1-sb11)1Mtay/0
TgTn(sb-T2/Onc3)12740Njen/0
involves: C3H * C57BL/6J * ICR MGI:5317024


Genotype
MGI:5317025
cn1
Allelic
Composition
Ptch1tm1Mps/Ptch1+
Tg(Atoh1-sb11)1Mtay/0
TgTn(sb-T2/Onc3)12740Njen/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Tg(Atoh1-sb11)1Mtay mutation (0 available)
TgTn(sb-T2/Onc3)12740Njen mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 271 of 279 mice develop medulloblastoma compared with 54 of 139 control mice with decreased latency (2.5 months compared with 8 months)

nervous system
• 271 of 279 mice develop medulloblastoma compared with 54 of 139 control mice with decreased latency (2.5 months compared with 8 months)




Genotype
MGI:5317026
cn2
Allelic
Composition
Tg(Atoh1-sb11)1Mtay/0
TgTn(sb-T2/Onc3)12740Njen/0
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129S2/SvPas * C3H * C57BL/6J * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Atoh1-sb11)1Mtay mutation (0 available)
TgTn(sb-T2/Onc3)12740Njen mutation (1 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• in some mice with large cells, nuclear atypia and nuclear moulding typical of large cell/anaplastic histology

nervous system
• in some mice with large cells, nuclear atypia and nuclear moulding typical of large cell/anaplastic histology




Genotype
MGI:5317024
cn3
Allelic
Composition
Tg(Atoh1-sb11)1Mtay/0
TgTn(sb-T2/Onc3)12740Njen/0
Genetic
Background
involves: C3H * C57BL/6J * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Atoh1-sb11)1Mtay mutation (0 available)
TgTn(sb-T2/Onc3)12740Njen mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice do not exhibit any tumors





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory