Phenotypes associated with this allele

• Allele Symbol: Gjc1^{tm1.1(Gjd2)Kwi}
• Allele Name: targeted mutation 1.1, Klaus Willecke
• Allele ID: MGI:5317162
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gjc1^tm1.1(Gjd2)Kwi/Gjc1^tm1.1(Gjd2)Kwi Tg(Myh6-cre)2182Mds/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5317174
cn2	Gjc1^tm1.1(Gjd2)Kwi/Gjc1^tm1.1(Gjd2)Kwi Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5317173

Genotype
MGI:5317174

cn1

• Allelic Composition: Gjc1^{tm1.1(Gjd2)Kwi}/Gjc1^{tm1.1(Gjd2)Kwi}; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:182927 )

• at E11.5

cardiovascular system

abnormal atrioventricular cushion morphology ( J:182927 )

• fewer endocardial cells in the endocardial cushion tissue compared to in wild-type mice

enlarged heart ( J:182927 )

pericardial effusion ( J:182927 )

• by E10.5 and E11.5

dilated heart ( J:182927 )

• mild by E10.5 and E11.5

decreased cardiac muscle contractility ( J:182927 )

• hearts contract weakly until E11.5

decreased heart rate ( J:182927 )

• at E10.5, the beating frequency of atria and ventricles is reduced compared to in wild-type mice

abnormal impulse conducting system conduction ( J:182927 )

• at E10.5, mice exhibit impaired transmission atrial contraction impulses into the ventricles compared with wild-type mice

atrioventricular block ( J:182927 )

• at E10.5, most mice exhibit 2:1 or 3:1 AV blocks

congestive heart failure ( J:182927 )

• suggested by pericardial effusion and heart dilation at E10.5 and E11.5

embryo

embryonic growth retardation ( J:182927 )

• at E10.5 and E11.5

decreased embryo size ( J:182927 )

• at E10.5 and E11.5

growth/size/body

enlarged heart ( J:182927 )

embryonic growth retardation ( J:182927 )

• at E10.5 and E11.5

decreased embryo size ( J:182927 )

• at E10.5 and E11.5

homeostasis/metabolism

pericardial effusion ( J:182927 )

• by E10.5 and E11.5

muscle

decreased cardiac muscle contractility ( J:182927 )

• hearts contract weakly until E11.5

Genotype
MGI:5317173

cn2

• Allelic Composition: Gjc1^{tm1.1(Gjd2)Kwi}/Gjc1^{tm1.1(Gjd2)Kwi}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

vision/eye

vision/eye phenotype ( J:182927 )

N • mice exhibit normal functional neurotransmitter coupling in the retina

N • mice exhibit normal electroretinograms

nervous system

nervous system phenotype ( J:182927 )

N • mice exhibit normal functional neurotransmitter coupling in the retina