Phenotypes associated with this allele

• Allele Symbol: S100a4^tm1.1Abres
• Allele Name: targeted mutation 1.1, Anne R Bresnick
• Allele ID: MGI:5317430
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	S100a4^tm1.1Abres/S100a4^tm1.1Abres	B6.Cg-S100a4^tm1.1Abres	MGI:5317431

Genotype
MGI:5317431

hm1

• Allelic Composition: S100a4^tm1.1Abres/S100a4^tm1.1Abres
• Genetic Background: B6.Cg-S100a4^tm1.1Abres

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired macrophage chemotaxis ( J:182865 )

• mice treated with thioglycollate exhibit impaired recruitment of macrophage compared with wild-type mice

• bone marrow macrophage exhibit defective CSF-1-stimulated motility with increased frequency but decreased persistence and size of protrusions and altered cytoskeletal response compared with wild-type cells

abnormal eosinophil physiology ( J:182865 )

• mice treated with thioglycollate exhibit increased eosinophil in the peritoneal exudate with wild-type mice

cellular

impaired macrophage chemotaxis ( J:182865 )

• mice treated with thioglycollate exhibit impaired recruitment of macrophage compared with wild-type mice

• bone marrow macrophage exhibit defective CSF-1-stimulated motility with increased frequency but decreased persistence and size of protrusions and altered cytoskeletal response compared with wild-type cells

hematopoietic system

impaired macrophage chemotaxis ( J:182865 )

• mice treated with thioglycollate exhibit impaired recruitment of macrophage compared with wild-type mice

• bone marrow macrophage exhibit defective CSF-1-stimulated motility with increased frequency but decreased persistence and size of protrusions and altered cytoskeletal response compared with wild-type cells

abnormal eosinophil physiology ( J:182865 )

• mice treated with thioglycollate exhibit increased eosinophil in the peritoneal exudate with wild-type mice