Phenotypes associated with this allele

• Allele Symbol: Tg(Igh-Mir155)8Cro
• Allele Name: transgene insertion 8, Carlo M Croce
• Allele ID: MGI:5317460
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Igh-Mir155)8Cro/0	involves: FVB/N	MGI:5317541

Genotype
MGI:5317541

tg1

• Allelic Composition: Tg(Igh-Mir155)8Cro/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell proliferation ( J:109591 )

• of pre-B cells at 3 weeks in the spleen and bone marrow

increased lymphoblastic lymphoma incidence ( J:109591 )

enlarged spleen ( J:109591 )

• as early as 3 weeks of age

abnormal lymphopoiesis ( J:109591 )

• polyclonal lymphoproliferation at 6 weeks

• increased in the spleen and bone marrow at 6 months

increased B cell number ( J:109591 )

• expansion of B220^low/CD10^low/IgM-/CD5-/TCR-/CD43- B cells in the spleen and bone marrow at 3, 6, and 7 weeks and 6 months

increased pre-B cell number ( J:109591 )

• at 6 months

decreased leukocyte cell number ( J:109591 )

• at 3 months

intermingled spleen red and white pulp ( J:109591 )

abnormal spleen B cell follicle morphology ( J:109591 )

• decreased splenic lymphoid follicles

decreased spleen white pulp amount ( J:109591 )

• replaced with red pulp at 6 months

increased spleen white pulp amount ( J:109591 )

• expands to replace white pulp at 6 months

neoplasm

increased lymphoblastic lymphoma incidence ( J:109591 )

increased B cell derived lymphoma incidence ( J:109591 )

• at 6 months, mice exhibit increased malignant lymphoid population with atypia and blastic appearance that proliferate in the vascular channels of the spleen red pulp and replace the white pulp

• high-grade B cell lymphoma at 6 months

hematopoietic system

increased B cell proliferation ( J:109591 )

• of pre-B cells at 3 weeks in the spleen and bone marrow

increased lymphoblastic lymphoma incidence ( J:109591 )

enlarged spleen ( J:109591 )

• as early as 3 weeks of age

abnormal lymphopoiesis ( J:109591 )

• polyclonal lymphoproliferation at 6 weeks

• increased in the spleen and bone marrow at 6 months

extramedullary hematopoiesis ( J:109591 )

• in the spleen

increased B cell number ( J:109591 )

• expansion of B220^low/CD10^low/IgM-/CD5-/TCR-/CD43- B cells in the spleen and bone marrow at 3, 6, and 7 weeks and 6 months

increased pre-B cell number ( J:109591 )

• at 6 months

decreased leukocyte cell number ( J:109591 )

• at 3 months

intermingled spleen red and white pulp ( J:109591 )

abnormal spleen B cell follicle morphology ( J:109591 )

• decreased splenic lymphoid follicles

decreased spleen white pulp amount ( J:109591 )

• replaced with red pulp at 6 months

increased spleen white pulp amount ( J:109591 )

• expands to replace white pulp at 6 months

growth/size/body

enlarged spleen ( J:109591 )

• as early as 3 weeks of age

endocrine/exocrine glands

increased lymphoblastic lymphoma incidence ( J:109591 )

cellular

increased B cell proliferation ( J:109591 )

• of pre-B cells at 3 weeks in the spleen and bone marrow