mortality/aging
• mice exhibit premature death compared with wild-type mice
• however, mice exhibit the same mortality as Krastm3Tyj heterozygotes
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neoplasm
• increased proliferation of tumor cells compared with tumor cells from Krastm3Tyj heterozygotes
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• at 18 weeks compared with Krastm3Tyj heterozygotes
• mice develop increased incidence of all tumor grades without increasing the rate of conversion to adenocarcinoma compared with Krastm3Tyj heterozygotes
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• of thymic tumors compared with Krastm3Tyj heterozygotes
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respiratory system
• mice develop increased incidence of all tumor grades without increasing the rate of conversion to adenocarcinoma compared with Krastm3Tyj heterozygotes
• at 18 weeks compared with Krastm3Tyj heterozygotes
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