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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Opa1tm1.2Hise
targeted mutation 1.2, Hiromi Sesaki
MGI:5317789
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Opa1tm1.2Hise/Opa1tm1.2Hise involves: 129S/SvEv * C57BL/6 * FVB/N MGI:5317793
cn2
 		Opa1tm1.1Hise/Opa1tm1.2Hise
Tg(Ins2-cre)25Mgn/0 		involves: 129S/SvEv * C57BL/6 * DBA * SJL MGI:5317794


Genotype
MGI:5317793
hm1
Allelic
Composition		 Opa1tm1.2Hise/Opa1tm1.2Hise
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opa1tm1.2Hise mutation (0 available); any Opa1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5317794
cn2
Allelic
Composition		 Opa1tm1.1Hise/Opa1tm1.2Hise
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opa1tm1.1Hise mutation (0 available); any Opa1 mutation (56 available)
Opa1tm1.2Hise mutation (0 available); any Opa1 mutation (56 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:183074 )
N
• following intraperitoneal insulin injection, mice exhibit normal insulin tolerance
decreased insulin secretion ( J:183074 )
• in glucose-stimulated beta cells and mice
• however, unstimulated insulin secretion is normal
increased circulating glucose level ( J:183074 )
• under fasted and fed conditions
• in a glucose tolerance test
decreased circulating insulin level ( J:183074 )
• following intraperitoneal glucose injection
decreased oxygen consumption ( J:183074 )
• in islets in response to glucose stimulation

endocrine/exocrine glands
abnormal pancreatic beta cell morphology ( J:183074 )
• decreased beta cell size and density
abnormal pancreatic beta cell physiology ( J:183074 )
• newborn mice exhibit decreased beta cell proliferation compared with control mice
• glucose-stimulated beta cells secrete less insulin compared with control cells
• beta cells exhibit impaired glucose-stimulated ATP production compared with control cells
• however, beta cells exhibit normal apoptosis and unstimulated insulin secretion
decreased pancreatic beta cell proliferation ( J:183074 )
• newborn mice exhibit decreased beta cell proliferation compared with control mice
decreased insulin secretion ( J:183074 )
• in glucose-stimulated beta cells and mice
• however, unstimulated insulin secretion is normal

cellular
abnormal mitochondrial morphology ( J:183074 )
• mitochondria in beta cells are highly fragmented, shorter with wider cristae compared to in control cells
• however, volume density of mitochondria is normal
abnormal mitochondrial crista morphology ( J:183074 )
• wider in beta cells compared with control cells
decreased pancreatic beta cell proliferation ( J:183074 )
• newborn mice exhibit decreased beta cell proliferation compared with control mice
abnormal respiratory electron transport chain ( J:183074 )
• islets exhibit decreased complex IV activity compared with control cells
• however, activity levels of complex I is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory