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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pld2tm1.1Mjow
targeted mutation 1.1, Michael JO Wakelam
MGI:5317803
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pld2tm1.1Mjow/Pld2tm1.1Mjow Not Specified MGI:5317804


Genotype
MGI:5317804
hm1
Allelic
Composition		 Pld2tm1.1Mjow/Pld2tm1.1Mjow
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld2tm1.1Mjow mutation (0 available); any Pld2 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil physiology ( J:183062 )
• neutrophils exhibit a small reduction in basal phosphatidic acid compared with wild-type mice
• however, production of phospatidic acids from neutrophils stimulated with PMA or fMLP is normal and production of reactive oxygen species is normal

hematopoietic system
abnormal neutrophil physiology ( J:183062 )
• neutrophils exhibit a small reduction in basal phosphatidic acid compared with wild-type mice
• however, production of phospatidic acids from neutrophils stimulated with PMA or fMLP is normal and production of reactive oxygen species is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory