Phenotypes associated with this allele

• Allele Symbol: Kmt2a^tm1.1Mlc
• Allele Name: targeted mutation 1.1, Michael L Cleary
• Allele ID: MGI:5317820
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kmt2a^tm1.1Mlc/Kmt2a^tm1.1Mlc	involves: 129P2/OlaHsd * C57BL/6	MGI:5317823
cx2	Kmt2a^tm1.1Mlc/Kmt2a^tm1.1Mlc Trp53^tm1Brd/Trp53^tm1Brd	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:5317824

Genotype
MGI:5317823

hm1

• Allelic Composition: Kmt2a^tm1.1Mlc/Kmt2a^tm1.1Mlc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:183048 )

• at E13 to E14

hematopoietic system

abnormal blood cell morphology/development ( J:183048 )

• reduced hematopoietic stem cell, multipotent progenitors and common myeloid progenitor cells in the fetal liver

• however, granulocyte-monocyte progenitor (GMP) or megakaryocyte-erythroid progenitor cells are partially restored

decreased common myeloid progenitor cell number ( J:183048 )

• in the fetal liver

decreased hematopoietic stem cell number ( J:183048 )

• in the fetal liver

abnormal hematopoietic stem cell physiology ( J:183048 )

• hematopoietic stem cell maintenance and expansion are impaired compared to in wild-type mice

• however, hematopoietic stem cell differentiation is normal

homeostasis/metabolism

skin edema ( J:183048 )

behavior/neurological

hunched posture ( J:183048 )

cardiovascular system

hemorrhage ( J:183048 )

cellular

early cellular replicative senescence ( J:183048 )

• in mouse embryonic fibroblasts

liver/biliary system

liver hypoplasia ( J:183048 )

integument

skin edema ( J:183048 )

Genotype
MGI:5317824

cx2

• Allelic Composition: Kmt2a^tm1.1Mlc/Kmt2a^tm1.1Mlc; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

cellular

cellular phenotype ( J:183048 )

N • early cellular replicative senescence observed in mouse embryonic fibroblasts is rescued