Phenotypes associated with this allele

• Allele Symbol: Tg(Scx-GFP/cre)1Stzr
• Allele Name: transgene insertion 1, Ronen Schweitzer
• Allele ID: MGI:5317938
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Adgrg6^tm1Arte/Adgrg6^tm1Arte Tg(Scx-GFP/cre)1Stzr/0	involves: 129S5/SvEvBrd	MGI:7266840
cn2	Adamtsl2^tm1c(KOMP)Wtsi/Adamtsl2^tm1c(KOMP)Wtsi Tg(Scx-GFP/cre)1Stzr/0	involves: C57BL/6 * C57BL/6N	MGI:6378828

Genotype
MGI:7266840

cn1

• Allelic Composition: Adgrg6^tm1Arte/Adgrg6^tm1Arte; Tg(Scx-GFP/cre)1Stzr/0
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal tendon physiology ( J:313834 )

• mechanically weaker tail tendons with reduced elastic moduli

skeleton

abnormal tendon physiology ( J:313834 )

• mechanically weaker tail tendons with reduced elastic moduli

abnormal intervertebral disk morphology ( J:313834 )

• mildly wedged in the curved region in scoliotic mice at P120

abnormal nucleus pulposus morphology ( J:313834 )

• shifted in the curved region in scoliotic mice at P120

scoliosis ( J:313834 )

• at P120 with curve severity ranged between 12 and 30 degrees

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
idiopathic scoliosis		DOID:0060250		J:313834

Genotype
MGI:6378828

cn2

• Allelic Composition: Adamtsl2^{tm1c(KOMP)Wtsi}/Adamtsl2^{tm1c(KOMP)Wtsi}; Tg(Scx-GFP/cre)1Stzr/0
• Genetic Background: involves: C57BL/6 * C57BL/6N

limbs/digits/tail

abnormal limb bone morphology ( J:280264 )

• several forelimb and hind limb bones are shorter, with an approximate 6% reduction in length

• however, disproportionate shortening of distal bones is not seen

short humerus ( J:280264 )

short radius ( J:280264 )

short ulna ( J:280264 )

short tibia ( J:280264 )

muscle

abnormal calcaneal tendon morphology ( J:280264 )

• Achilles tendons are shorter, however their width does not differ

skeleton

abnormal limb bone morphology ( J:280264 )

• several forelimb and hind limb bones are shorter, with an approximate 6% reduction in length

• however, disproportionate shortening of distal bones is not seen

short humerus ( J:280264 )

short radius ( J:280264 )

short ulna ( J:280264 )

short tibia ( J:280264 )

abnormal calcaneal tendon morphology ( J:280264 )

• Achilles tendons are shorter, however their width does not differ