Phenotypes associated with this allele

• Allele Symbol: Acot11^tm1Deco
• Allele Name: targeted mutation 1, David E Cohen
• Allele ID: MGI:5317949
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acot11^tm1Deco/Acot11^tm1Deco	involves: 129S6/SvEvTac * C57BL/6	MGI:5317950

Genotype
MGI:5317950

hm1

• Allelic Composition: Acot11^tm1Deco/Acot11^tm1Deco
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased lean body mass ( J:182660 )

• modest decrease in mice on a high fat diet compared to diet matched controls

decreased susceptibility to diet-induced obesity ( J:182660 )

• when fed a high fat diet

• however, on a normal chow diet growth is similar to diet matched controls

behavior/neurological

behavior/neurological phenotype ( J:182660 )

N • on both chow and high fat diets total and ambulatory activity levels are similar to controls

increased food intake ( J:182660 )

• on either a normal chow or high fat diet consume nearly twice as much food as diet matched controls

adipose tissue

abnormal brown adipose tissue morphology ( J:182660 )

• increase in the concentration of the most abundant long-chain fatty acyl-CoA [linoleoyl (C18:2)-CoA]

increased brown adipose tissue amount ( J:182660 )

• increase in the proportion of brown fat in chow fed mice

abnormal brown fat cell morphology ( J:182660 )

• increase in mitochondrial content when on a high fat diet

decreased brown fat cell lipid droplet size ( J:182660 )

increased adipocyte glucose uptake ( J:182660 )

• increased uptake in cultured brown adipocytes

abnormal brown adipose tissue physiology ( J:182660 )

• increase in fatty acid oxidation rates in brown adipose tissue

abnormal brown adipose tissue thermogenesis ( J:182660 )

• expression analysis indicates an increase in thermogenesis in brown adipose tissue when on a high fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:182660 )

N • on both chow and high fat diets plasma concentration of thyroid hormones are similar to controls

increased fatty acid oxidation ( J:182660 )

• increase in fatty acid oxidation rates in brown adipose tissue

decreased circulating glucose level ( J:182660 )

• decreased fasting glucose levels in mice fed a chow diet or a high fat diet

• however, no difference is detected in plasma insulin levels

decreased circulating cholesterol level ( J:182660 )

• in mice fed a chow diet or a high fat diet

decreased circulating HDL cholesterol level ( J:182660 )

increased circulating triglyceride level ( J:182660 )

• in mice fed a high fat diet

increased energy expenditure ( J:182660 )

• heat production is increased during the light phase in chow fed mice and in the light and dark phases in mice on a high fat diet

decreased susceptibility to diet-induced obesity ( J:182660 )

• when fed a high fat diet

• however, on a normal chow diet growth is similar to diet matched controls

increased oxygen consumption ( J:182660 )

• during the light phase in chow fed mice

• the decrease in VO2 induced by a high fat diet in wild-type controls is nearly eliminated

increased respiratory quotient ( J:182660 )

• increase in the respiratory exchange rate during the light phase in mice on a chow diet and during the dark phase in mice on a high fat diet

improved glucose tolerance ( J:182660 )

• in mice fed a chow diet or a high fat diet

increased fatty acids level ( J:182660 )

• increase in the concentration of the most abundant long-chain fatty acyl-CoA [linoleoyl (C18:2)-CoA] in brown adipose tissue

decreased physiological sensitivity to xenobiotic ( J:182660 )

• decrease in the ER stress response in livers and MEFs treated with tunicamycin and thapsigargin

cellular

increased adipocyte glucose uptake ( J:182660 )

• increased uptake in cultured brown adipocytes

increased fatty acid oxidation ( J:182660 )

• increase in fatty acid oxidation rates in brown adipose tissue

immune system

decreased inflammatory response ( J:182660 )

• in white adipose tissue and liver in mice on a high fat diet

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:182660 )

• in mice on a high fat diet compared to diet matched controls