Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^tm1(sb13)Tuv
• Allele Name: targeted mutation 1, David A Tuveson
• Allele ID: MGI:5318064
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm4Tyj/Kras^+ Gt(ROSA)26Sor^tm1(sb13)Tuv/Gt(ROSA)26Sor^+ Tg(Pdx1-cre)6Tuv/0 TgTn(sb-T2/Onc)#Dla/0	involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N	MGI:5438089
cn2	Braf^tm1Tuv/Braf^tm1Tuv Gt(ROSA)26Sor^tm1(sb13)Tuv/Gt(ROSA)26Sor^+ Tg(Tyr-cre/ERT2)13Bos/0 TgTn(sb-T2/Onc)#Dla/0	involves: 129S6/SvEvTac * FVB/N	MGI:5318067

Genotype
MGI:5438089

cn1

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Gt(ROSA)26Sor^tm1(sb13)Tuv/Gt(ROSA)26Sor⁺; Tg(Pdx1-cre)6Tuv/0; TgTn(sb-T2/Onc)#Dla/0
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:186717 )

• mice succumb to invasive pancreatic neoplasms

neoplasm

increased pancreas tumor incidence ( J:186717 )

• rapid progression, multi-focal and invasive

• pancreatic ductal adenocarcinoma or invasive cystic neoplasms with metastasis to the liver and lungs

increased pancreatic ductal adenocarcinoma incidence ( J:186717 )

increased pancreatic intraepithelial neoplasia incidence ( J:186717 )

endocrine/exocrine glands

increased pancreas tumor incidence ( J:186717 )

• rapid progression, multi-focal and invasive

• pancreatic ductal adenocarcinoma or invasive cystic neoplasms with metastasis to the liver and lungs

increased pancreatic ductal adenocarcinoma incidence ( J:186717 )

increased pancreatic intraepithelial neoplasia incidence ( J:186717 )

Genotype
MGI:5318067

cn2

• Allelic Composition: Braf^tm1Tuv/Braf^tm1Tuv; Gt(ROSA)26Sor^tm1(sb13)Tuv/Gt(ROSA)26Sor⁺; Tg(Tyr-cre/ERT2)13Bos/0; TgTn(sb-T2/Onc)#Dla/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

neoplasm

increased melanoma incidence ( J:177503 )

• in tamoxifen-treated mice