Phenotypes associated with this allele

• Allele Symbol: Cdk1^tm2.1Kald
• Allele Name: targeted mutation 2.1, Philipp Kaldis
• Allele ID: MGI:5318085
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Tg(CAG-cre/Esr1*)5Amc/0	involves: 129 * C57BL/6 * CBA * SJL	MGI:5318110
cn2	Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129 * C57BL/6 * DBA * SJL	MGI:5318109

Genotype
MGI:5318110

cn1

• Allelic Composition: Cdk1^tm2.1Kald/Cdk1^tm2.1Kald; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased cell proliferation ( J:182141 )

• in mouse embryonic fibroblasts treated with tamoxifen

early cellular replicative senescence ( J:182141 )

• in mouse embryonic fibroblasts treated with tamoxifen

abnormal DNA replication ( J:182141 )

• tamoxifen-treated mouse embryonic fibroblasts fail to exhibit DNA re-replication unlike control cells

• however, initial DNA replication is normal

neoplasm

decreased tumor growth/size ( J:182141 )

• following tamoxifen treatment of tumor cells induced by activated Ras

homeostasis/metabolism

abnormal DNA replication ( J:182141 )

• tamoxifen-treated mouse embryonic fibroblasts fail to exhibit DNA re-replication unlike control cells

• however, initial DNA replication is normal

Genotype
MGI:5318109

cn2

• Allelic Composition: Cdk1^tm2.1Kald/Cdk1^tm2.1Kald; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129 * C57BL/6 * DBA * SJL

Livers of Cdk1^tm2.1Kald/Cdk1^tm2.1Kald Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice conatin fewer hepatocytes

liver/biliary system

decreased hepatocyte proliferation ( J:182141 )

• following partial hepatectomy, hepatocytes fail to enter cell division unlike control cells

• however, DNA replication is normal

abnormal hepatocyte morphology ( J:182141 )

• in untreated mice and following partial hepatectomy, hepatocytes exhibit increased nuclei diameter and decreased cell density compared with control cells

decreased hepatocyte number ( J:182141 )

• in untreated mice and following partial hepatectomy

cellular

polyploidy ( J:182141 )

• in hepatocytes following partial hepatectomy

abnormal mitosis ( J:182141 )

• following partial hepatectomy, hepatocytes fail to enter mitosis unlike control cells

decreased hepatocyte proliferation ( J:182141 )

• following partial hepatectomy, hepatocytes fail to enter cell division unlike control cells

• however, DNA replication is normal

neoplasm

decreased incidence of induced tumors ( J:182141 )

• following tail-vein injection of activated Ras, mice fail to develop liver tumors unlike control mice

homeostasis/metabolism

abnormal response to injury ( J:182141 )

• following partial hepatectomy, hepatocytes fail to enter cell division unlike control cells

• however, liver regeneration is achieved through cell growth