Phenotypes associated with this allele

• Allele Symbol: Stab2^tm1Ami
• Allele Name: targeted mutation 1, Atsushi Miyajima
• Allele ID: MGI:5318244
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stab2^tm1Ami/Stab2^tm1Ami	B6.Cg-Stab2^tm1Ami	MGI:5318245

Genotype
MGI:5318245

hm1

• Allelic Composition: Stab2^tm1Ami/Stab2^tm1Ami
• Genetic Background: B6.Cg-Stab2^tm1Ami

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating hyaluronic acid level ( J:182239 )

• dramatic increase in serum hyaluronic acid levels

liver/biliary system

abnormal hepatocyte physiology ( J:182239 )

• marked decrease in the internalization of hyaluronic acid in hepatic sinusoid endothelial cells indicating a defect in endocytosis

neoplasm

decreased metastatic potential ( J:182239 )

• 14 days after i.v. inoculation with B16F10 melanoma cells fewer black nodules form on the lung surface; however, tumor formation after subcutaneous inoculation with B16F10 melanoma cells does not differ from wild-type mice indicating a decrease in metastasis