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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ltbrtm1.1Thhe
targeted mutation 1.1, Thomas Hehlgans
MGI:5318395
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ltbrtm1.1Thhe/Ltbrtm1.1Thhe involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5318483
cn2
 		Ltbrtm1.1Thhe/Ltbrtm1.1Thhe
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5318484


Genotype
MGI:5318483
hm1
Allelic
Composition		 Ltbrtm1.1Thhe/Ltbrtm1.1Thhe
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbrtm1.1Thhe mutation (0 available); any Ltbr mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:183109 )
• healthy and fertile




Genotype
MGI:5318484
cn2
Allelic
Composition		 Ltbrtm1.1Thhe/Ltbrtm1.1Thhe
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbrtm1.1Thhe mutation (0 available); any Ltbr mutation (47 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:183109 )
• macrophage exhibit induced tolerance to TLR4 and TLR9 ligands measured by hyporesponsiveness for the induction of TNF and IL6 after restimulation with LPS or CpG compared with control cells

hematopoietic system
abnormal macrophage physiology ( J:183109 )
• macrophage exhibit induced tolerance to TLR4 and TLR9 ligands measured by hyporesponsiveness for the induction of TNF and IL6 after restimulation with LPS or CpG compared with control cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory