Phenotypes associated with this allele

• Allele Symbol: Sulf1^tm1Mmas
• Allele Name: targeted mutation 1, Masayuki Masu
• Allele ID: MGI:5318489
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sulf1^tm1Mmas/Sulf1^tm1Mmas	B6N.129P2-Sulf1^tm1Mmas	MGI:5318494
cx2	Sulf1^tm1Mmas/Sulf1^tm1Mmas Sulf2^tm1Mmas/Sulf2^tm1Mmas	B6N.129P2-Sulf1^tm1Mmas Sulf2^tm1Mmas	MGI:5318496

Genotype
MGI:5318494

hm1

• Allelic Composition: Sulf1^tm1Mmas/Sulf1^tm1Mmas
• Genetic Background: B6N.129P2-Sulf1^tm1Mmas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell morphology ( J:183277 )

• mice exhibit an accumulation of deltaUA2S-GlcNS6S in the brain, small intestine, lung, spleen, testis and skeletal muscle compared with wild-type mice

• mice exhibit an accumulation of deltaUA-GlcNS6S in the lung and small intestine compared with wild-type mice

• changes in heparin sulfate composition are greater than in Sulf2^tm1Mmas homozygotes

Genotype
MGI:5318496

cx2

• Allelic Composition: Sulf1^tm1Mmas/Sulf1^tm1Mmas; Sulf2^tm1Mmas/Sulf2^tm1Mmas
• Genetic Background: B6N.129P2-Sulf1^tm1Mmas Sulf2^tm1Mmas

cellular

abnormal cell morphology ( J:183277 )

• mice exhibit an accumulation of deltaUA2S-GlcNS6S in the brain, liver, kidney, spleen and testis compared with wild-type mice

• changes in heparin sulfate composition are not as great as in Sulf2^tm1Mmas homozygotes