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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sulf2tm1Mmas
targeted mutation 1, Masayuki Masu
MGI:5318490
Summary 2 genotypes


Genotype
MGI:5318495
hm1
Allelic
Composition		 Sulf2tm1Mmas/Sulf2tm1Mmas
Genetic
Background		 B6N.129P2-Sulf2tm1Mmas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sulf2tm1Mmas mutation (0 available); any Sulf2 mutation (177 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cellular
abnormal cell morphology ( J:183277 )
• mice exhibit an accumulation of deltaUA2S-GlcNS6S in the lung, liver and kidney compared with wild-type mice
• mice exhibit a decrease in the percentages of deltaUA-GlcNS6S and deltaUA-GlcNAc6S in the liver compared with wild-type mice




Genotype
MGI:5318496
cx2
Allelic
Composition		 Sulf1tm1Mmas/Sulf1tm1Mmas
Sulf2tm1Mmas/Sulf2tm1Mmas
Genetic
Background		 B6N.129P2-Sulf1tm1Mmas Sulf2tm1Mmas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sulf1tm1Mmas mutation (0 available); any Sulf1 mutation (112 available)
Sulf2tm1Mmas mutation (0 available); any Sulf2 mutation (177 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell morphology ( J:183277 )
• mice exhibit an accumulation of deltaUA2S-GlcNS6S in the brain, liver, kidney, spleen and testis compared with wild-type mice
• changes in heparin sulfate composition are not as great as in Sulf2tm1Mmas homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory