Phenotypes associated with this allele

• Allele Symbol: Slc12a6^tm1.1Garo
• Allele Name: targeted mutation 1.1, Guy A Rouleau
• Allele ID: MGI:5318539
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo	involves: 129 * C57BL/6	MGI:5318541

Genotype
MGI:5318541

hm1

• Allelic Composition: Slc12a6^tm1.1Garo/Slc12a6^tm1.1Garo
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

infertility ( J:183239 )

• unable to successfully breed

nervous system

abnormal nervous system morphology ( J:183239 )

• progressive peripheral neuropathy starting at 3-4 weeks of age

increased brain weight ( J:183239 )

• at 2 months of age

abnormal corpus callosum morphology ( J:183239 )

• the position in relation to the anterior commissure appears to be shifted

• significant decrease in the number of streamlines from the splenium passing through the external capsule adjacent to the somatosensory cortices

decreased corpus callosum size ( J:183239 )

• hypoplastic with reduced length and surface area

abnormal axon morphology ( J:183239 )

• axon swelling in sciatic nerves

abnormal sciatic nerve morphology ( J:183239 )

• axon degeneration, hypomyelination and axon swelling in sciatic nerves

axon degeneration ( J:183239 )

• in sciatic nerves

demyelination ( J:183239 )

• hypomyelination in sciatic nerves

behavior/neurological

abnormal startle reflex ( J:183239 )

• baseline startle response is increased but mice fail increase startle amplitude with increasing intensities

limb grasping ( J:183239 )

• by 3-4 weeks of age

impaired coordination ( J:183239 )

abnormal locomotor behavior ( J:183239 )

• severe locomotor deficiencies

• deficiencies become more severe after 8 months of age

increased locomotor activity ( J:183239 )

• significant increase in the total distance traveled and the number of movement bouts at 5 months of age

decreased chemical nociceptive threshold ( J:183239 )

• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain

growth/size/body

decreased body weight ( J:183239 )

• at 2 months of age