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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tph2tm1Mscl
targeted mutation 1, Michael S Clark
MGI:5318587
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Agrptm2(HBEGF)Rpa/Agrp+
Tph2tm1Mscl/Tph2tm1Mscl
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr MGI:5427450


Genotype
MGI:5427450
cn1
Allelic
Composition
Agrptm2(HBEGF)Rpa/Agrp+
Tph2tm1Mscl/Tph2tm1Mscl
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrptm2(HBEGF)Rpa mutation (1 available); any Agrp mutation (17 available)
Tph2tm1Mscl mutation (0 available); any Tph2 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries

growth/size/body
• diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries prevents starvation induced by AgRP neuron ablation unlike in control mice

homeostasis/metabolism
• in diphtheria-treated mice injected with a virus expressing a CAV2-cre into the nucleus tractus solitaries





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory