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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tbxa2rtm1.1Bhk
targeted mutation 1.1, Beverly H Koller
MGI:5319073
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tbxa2rtm1Cof/Tbxa2rtm1.1Bhk
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL MGI:5319079
cn2
Tbxa2rtm1Cof/Tbxa2rtm1.1Bhk
Tg(Tagln-cre)1Her/0
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL MGI:5319080


Genotype
MGI:5319079
cn1
Allelic
Composition
Tbxa2rtm1Cof/Tbxa2rtm1.1Bhk
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbxa2rtm1.1Bhk mutation (1 available); any Tbxa2r mutation (18 available)
Tbxa2rtm1Cof mutation (0 available); any Tbxa2r mutation (18 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• mice exposed to ovalbumin and U-46619 fail to exhibit increased airway resistance unlike control mice
• however, mice exposed to increasing doses of thromboxane receptor agonist U-46619 exhibit dose-dependent increase in airway resistance




Genotype
MGI:5319080
cn2
Allelic
Composition
Tbxa2rtm1Cof/Tbxa2rtm1.1Bhk
Tg(Tagln-cre)1Her/0
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbxa2rtm1.1Bhk mutation (1 available); any Tbxa2r mutation (18 available)
Tbxa2rtm1Cof mutation (0 available); any Tbxa2r mutation (18 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• mice exposed to increasing doses of thromboxane receptor agonist U-46619 exhibit an attenuated dose-dependent increase in airway resistance unlike control mice
• mice exposed to U-46619 and methacholine exhibit less of an increased in airway resistance compared with control mice
• however, mice exposed ovalbumin and U-46619 exhibit dose-dependent increase in airway resistance





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory