Phenotypes associated with this allele

• Allele Symbol: Ptpn2^tm1.1Kry
• Allele Name: targeted mutation 1.1, Gerard Karsenty
• Allele ID: MGI:5319222
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptpn2^tm1.1Kry/Ptpn2^tm1.1Kry Tg(Col1a1-cre)1Kry/0	involves: 129 * C57BL/6J * FVB	MGI:5319229

Genotype
MGI:5319229

cn1

• Allelic Composition: Ptpn2^tm1.1Kry/Ptpn2^tm1.1Kry; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: 129 * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:183709 )

N • mice fed standard chow or a high fat diet exhibit normal glucose tolerance

increased circulating osteocalcin level ( J:183709 )

• mice exhibit increased serum level of undercarboxylated (i.e. active) ostecalcin compared with wild-type mice

increased energy expenditure ( J:183709 )

• during the day but not night

increased carbon dioxide production ( J:183709 )

• during the day but not night

increased oxygen consumption ( J:183709 )

• during the day but not night

increased insulin sensitivity ( J:183709 )

skeleton

skeleton phenotype ( J:183709 )

N • osteoblast differentiation and proliferation are normal

abnormal osteoclast differentiation ( J:183709 )

• osteoblasts co-cultured with wild-type monocyte in the presence of vitamin D3 and prostaglandin E2 exhibit increased osteoclast differentiation compared with wild-type osteoblasts

• however, osteoclast number in vivo is normal

abnormal osteoclast physiology ( J:183709 )

• increased activity

increased bone resorption ( J:183709 )

• due to increased osteoclast activity

immune system

abnormal osteoclast differentiation ( J:183709 )

• osteoblasts co-cultured with wild-type monocyte in the presence of vitamin D3 and prostaglandin E2 exhibit increased osteoclast differentiation compared with wild-type osteoblasts

• however, osteoclast number in vivo is normal

abnormal osteoclast physiology ( J:183709 )

• increased activity

cellular

abnormal osteoclast differentiation ( J:183709 )

• osteoblasts co-cultured with wild-type monocyte in the presence of vitamin D3 and prostaglandin E2 exhibit increased osteoclast differentiation compared with wild-type osteoblasts

• however, osteoclast number in vivo is normal

hematopoietic system

abnormal osteoclast differentiation ( J:183709 )

• osteoblasts co-cultured with wild-type monocyte in the presence of vitamin D3 and prostaglandin E2 exhibit increased osteoclast differentiation compared with wild-type osteoblasts

• however, osteoclast number in vivo is normal

abnormal osteoclast physiology ( J:183709 )

• increased activity