All Phenotypes Hprt1<tm86(NR2E1,bEMS223)Ems> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hprt1^{tm86(NR2E1,bEMS223)Ems}
targeted mutation 86, Elizabeth M Simpson
MGI:5319310

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hprt1^{tm86(NR2E1,bEMS223)Ems}/Y Nr2e1^frc/Nr2e1^frc	involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6	MGI:5427454
ot2	Hprt1^{tm86(NR2E1,bEMS223)Ems}/Y	B6.Cg-Hprt1^{tm86(NR2E1,bEMS223)Ems}	MGI:5427453

Allelic Composition	Hprt1^{tm86(NR2E1,bEMS223)Ems}/Y Nr2e1^frc/Nr2e1^frc
Genetic Background	involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm86(NR2E1,bEMS223)Ems} mutation (0 available); any Hprt1 mutation (1279 available)
Nr2e1^frc mutation (2 available); any Nr2e1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal precursor proliferation ( J:183689 )

• decreased in the lateral ventricle and dentate gyrus

abnormal cerebral hemisphere morphology ( J:183689 )

• decrease in size that is not as severe as in Nr2e1^frc homozygotes

small olfactory bulb ( J:183689 )

• not as severe as in Nr2e1^frc homozygotes

cardiovascular system

cardiovascular system phenotype ( J:183689 )

N	• mice exhibit normal numbers of retinal vessels and radial symmetry unlike Nr2e1^frc homozygotes

vision/eye

vision/eye phenotype ( J:183689 )

N	• mice exhibit normal retina morphology and physiology unlike Nr2e1^frc homozygotes

cellular

abnormal neuronal precursor proliferation ( J:183689 )

• decreased in the lateral ventricle and dentate gyrus

Allelic Composition	Hprt1^{tm86(NR2E1,bEMS223)Ems}/Y
Genetic Background	B6.Cg-Hprt1^{tm86(NR2E1,bEMS223)Ems}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm86(NR2E1,bEMS223)Ems} mutation (0 available); any Hprt1 mutation (1279 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:183689 )

N	• mice exhibit normal olfactory bulb and cerebrum size

abnormal neuronal precursor proliferation ( J:183689 )

• decreased in the lateral ventricle and dentate gyrus

cardiovascular system

cardiovascular system phenotype ( J:183689 )

N	• mice exhibit normal numbers of retinal vessels and radial symmetry

vision/eye

vision/eye phenotype ( J:183689 )

N	• mice exhibit normal retina morphology and physiology

cellular

abnormal neuronal precursor proliferation ( J:183689 )

• decreased in the lateral ventricle and dentate gyrus

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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