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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm86(NR2E1,bEMS223)Ems
targeted mutation 86, Elizabeth M Simpson
MGI:5319310
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Hprt1tm86(NR2E1,bEMS223)Ems/Y
Nr2e1frc/Nr2e1frc 		involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6 MGI:5427454
ot2
 		Hprt1tm86(NR2E1,bEMS223)Ems/Y B6.Cg-Hprt1tm86(NR2E1,bEMS223)Ems MGI:5427453


Genotype
MGI:5427454
cx1
Allelic
Composition		 Hprt1tm86(NR2E1,bEMS223)Ems/Y
Nr2e1frc/Nr2e1frc
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm86(NR2E1,bEMS223)Ems mutation (0 available); any Hprt1 mutation (1281 available)
Nr2e1frc mutation (2 available); any Nr2e1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal precursor proliferation ( J:183689 )
• decreased in the lateral ventricle and dentate gyrus
abnormal cerebral hemisphere morphology ( J:183689 )
• decrease in size that is not as severe as in Nr2e1frc homozygotes
small olfactory bulb ( J:183689 )
• not as severe as in Nr2e1frc homozygotes

cardiovascular system
cardiovascular system phenotype ( J:183689 )
N
• mice exhibit normal numbers of retinal vessels and radial symmetry unlike Nr2e1frc homozygotes

vision/eye
vision/eye phenotype ( J:183689 )
N
• mice exhibit normal retina morphology and physiology unlike Nr2e1frc homozygotes

cellular
abnormal neuronal precursor proliferation ( J:183689 )
• decreased in the lateral ventricle and dentate gyrus




Genotype
MGI:5427453
ot2
Allelic
Composition		 Hprt1tm86(NR2E1,bEMS223)Ems/Y
Genetic
Background		 B6.Cg-Hprt1tm86(NR2E1,bEMS223)Ems
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm86(NR2E1,bEMS223)Ems mutation (0 available); any Hprt1 mutation (1281 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:183689 )
N
• mice exhibit normal olfactory bulb and cerebrum size
abnormal neuronal precursor proliferation ( J:183689 )
• decreased in the lateral ventricle and dentate gyrus

cardiovascular system
cardiovascular system phenotype ( J:183689 )
N
• mice exhibit normal numbers of retinal vessels and radial symmetry

vision/eye
vision/eye phenotype ( J:183689 )
N
• mice exhibit normal retina morphology and physiology

cellular
abnormal neuronal precursor proliferation ( J:183689 )
• decreased in the lateral ventricle and dentate gyrus




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory