mortality/aging
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• mice die by E15.5
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Allele Symbol Allele Name Allele ID |
Birc2tm1.1Rbr targeted mutation 1.1, Robert Brink MGI:5319370 |
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Summary |
11 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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• mice die by E15.5
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
• most mice die within 10 weeks of birth
• however, two mice survive for 6 weeks
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• two surviving mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice survive to E12.5
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice survive to E15.5
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
• around E10.5
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• sporadic discontinuities associated with pyknotic nuclei suggestive of apoptosis, usually in the atrial chamber
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• between E10.5 and E11.5, many mice exhibit swollen pericardial cavities filled with blood unlike in wild-type mice
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|
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• between E10.5 and E11.5
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• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice
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• between E10.5 and E11.5
|
|
• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice survive to E12.5
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice survive to E15.5
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• around E10.5
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are viable with no reproductive or developmental defects
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• around E10.5
|
• sporadic discontinuities associated with pyknotic nuclei suggestive of apoptosis, usually in the atrial chamber
|
• between E10.5 and E11.5, many mice exhibit swollen pericardial cavities filled with blood unlike in wild-type mice
|
• between E10.5 and E11.5
|
• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice
|
• between E10.5 and E11.5
|
• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• while mice are born alive none survive to weaning
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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