Phenotypes associated with this allele

• Allele Symbol: Cdk2^tm1.1Jro
• Allele Name: targeted mutation 1.1, James Roberts
• Allele ID: MGI:5319654
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk2^tm1.1Jro/Cdk2^tm1.1Jro	involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6	MGI:5319675
ht2	Cdk2^tm1.1Jro/Cdk2^+	involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6	MGI:5319676

Genotype
MGI:5319675

hm1

• Allelic Composition: Cdk2^tm1.1Jro/Cdk2^tm1.1Jro
• Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:183801 )

growth/size/body

decreased body weight ( J:183801 )

• slight

cellular

cellular phenotype ( J:183801 )

N • mouse embryonic fibroblasts exhibit normal cell cycle progression

Genotype
MGI:5319676

ht2

• Allelic Composition: Cdk2^tm1.1Jro/Cdk2⁺
• Genetic Background: involves: 129S1/SvlmJ * 129S4/SvJaeSor * C57BL/6

reproductive system

reproductive system phenotype ( J:183801 )

N • female mice exhibit normal fertility

azoospermia ( J:183801 )

♂

testicular atrophy ( J:183801 )

♂

reduced male fertility ( J:183801 )

♂ • Background Sensitivity: mice on a mixed background exhibit reduced male fertility compared with mice backcrossed onto the 129S1/SmJ and C57BL/6 background (no generation number specified)

endocrine/exocrine glands

testicular atrophy ( J:183801 )

♂

cellular

azoospermia ( J:183801 )

♂