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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir708tm1Wtsi
targeted mutation 1, Wellcome Trust Sanger Institute
MGI:5320130
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		ApcMin/Apc+
Mir708tm1Wtsi/Mir708tm1Wtsi 		involves: C57BL/6J * C57BL/6N MGI:6864129


Genotype
MGI:6864129
cx1
Allelic
Composition		 ApcMin/Apc+
Mir708tm1Wtsi/Mir708tm1Wtsi
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Mir708tm1Wtsi mutation (0 available); any Mir708 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:317482 )
• not as much as in ApcMin heterozygotes

neoplasm
increased colon adenoma incidence ( J:317482 )
• not as much as in ApcMin heterozygotes with reduced lethality

digestive/alimentary system
increased colon adenoma incidence ( J:317482 )
• not as much as in ApcMin heterozygotes with reduced lethality
abnormal intestinal epithelium physiology ( J:317482 )
• reduced organoid formation from crypt cells from AOM/DSS-induced colorectal cancer model mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory