All Phenotypes Megf10<tm1a(KOMP)Jrs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Megf10^{tm1a(KOMP)Jrs}
targeted mutation 1a, Joshua R Sanes
MGI:5320335

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Megf10^{tm1a(KOMP)Jrs}/Megf10^{tm1a(KOMP)Jrs}	involves: 129S4/SvJae * C57BL/6	MGI:5320416
ht2	Megf10^{tm1a(KOMP)Jrs}/Megf10⁺	involves: 129S4/SvJae * C57BL/6	MGI:5320417
cx3	Megf10^{tm1a(KOMP)Jrs}/Megf10^{tm1a(KOMP)Jrs} Megf11^{tm1a(EUCOMM)Wtsi}/Megf11^{tm1a(EUCOMM)Wtsi}	involves: 129S4/SvJae * C57BL/6 * C57BL/6N	MGI:5320415

Allelic Composition	Megf10^{tm1a(KOMP)Jrs}/Megf10^{tm1a(KOMP)Jrs}
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf10^{tm1a(KOMP)Jrs} mutation (1 available); any Megf10 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal amacrine cell morphology ( J:182578 )

• the SAC exclusion zone is smaller than in wild-type mice

• SAC arrays and somas are disorganized compared to in wild-type mice

• mice exhibit loss of regular spacing among starburst amacrine cells (SAC) somata compared with wild-type mice

• however, other amacrine cells types exhibit normal mosaic spacing

abnormal retina horizontal cell morphology ( J:182578 )

• regularity is modestly affected

vision/eye

abnormal amacrine cell morphology ( J:182578 )

• the SAC exclusion zone is smaller than in wild-type mice

• SAC arrays and somas are disorganized compared to in wild-type mice

• mice exhibit loss of regular spacing among starburst amacrine cells (SAC) somata compared with wild-type mice

• however, other amacrine cells types exhibit normal mosaic spacing

abnormal retina horizontal cell morphology ( J:182578 )

• regularity is modestly affected

Allelic Composition	Megf10^{tm1a(KOMP)Jrs}/Megf10⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf10^{tm1a(KOMP)Jrs} mutation (1 available); any Megf10 mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal amacrine cell morphology ( J:182578 )

• starburst amacrine cells arrays are mildly disorganized compared to in wild-type mice

vision/eye

abnormal amacrine cell morphology ( J:182578 )

• starburst amacrine cells arrays are mildly disorganized compared to in wild-type mice

Allelic Composition	Megf10^{tm1a(KOMP)Jrs}/Megf10^{tm1a(KOMP)Jrs} Megf11^{tm1a(EUCOMM)Wtsi}/Megf11^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: 129S4/SvJae * C57BL/6 * C57BL/6N
Cell Lines	EPD0428_3_D07, EPD0428_3_C05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf10^{tm1a(KOMP)Jrs} mutation (1 available); any Megf10 mutation (69 available)
Megf11^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Megf11 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal amacrine cell morphology ( J:182578 )

• starburst amacine cells exhibit abnormal spacing as in Megf10^{tm1a(KOMP)Jrs} homozygotes

abnormal retina horizontal cell morphology ( J:182578 )

• horizontal cell mosaic is severely disrupted compared with wild-type mice

vision/eye

abnormal amacrine cell morphology ( J:182578 )

• starburst amacine cells exhibit abnormal spacing as in Megf10^{tm1a(KOMP)Jrs} homozygotes

abnormal retina horizontal cell morphology ( J:182578 )

• horizontal cell mosaic is severely disrupted compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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