Phenotypes associated with this allele

• Allele Symbol: Isl1^tm2.1Sev
• Allele Name: targeted mutation 2.1, Sylvia M Evans
• Allele ID: MGI:5320481
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Isl1^tm2Sev/Isl1^tm2.1Sev Tg(Hoxb6-cre)#Mku/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5320482

Genotype
MGI:5320482

cn1

• Allelic Composition: Isl1^tm2Sev/Isl1^tm2.1Sev; Tg(Hoxb6-cre)#Mku/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal hindlimb bud morphology ( J:184018 )

• expression analysis indicates proximal patterning defects in the hindlimb buds

hindlimb oligodactyly ( J:184018 )

• variable severity of hindlimb digit loss

• almost half of mice display hindlimbs with only 3 digits

• less severely affected mice develop 4 hindlimb digits, lacking the posterior digit 5

abnormal hindlimb zeugopod morphology ( J:184018 )

• only a single zeugopodal element, likely corresponding to the tibia, is present in most mice with 1 - 3 digits on the hindlimb

• mice with 4 digits on the hindlimb show more variability in zeugopodal defects

absent hindlimb ( J:184018 )

• in severely affected mice

embryo

abnormal hindlimb bud morphology ( J:184018 )

• expression analysis indicates proximal patterning defects in the hindlimb buds

skeleton

abnormal ischium morphology ( J:184018 )

• patterning failure

absent pubis ( J:184018 )

• patterning failure