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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbtb46tm1Kmm
targeted mutation 1, Kenneth Murphy
MGI:5320483
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zbtb46tm1Kmm/Zbtb46tm1Kmm 129S/SvEv-Zbtb46tm1Kmm MGI:5320499


Genotype
MGI:5320499
hm1
Allelic
Composition		 Zbtb46tm1Kmm/Zbtb46tm1Kmm
Genetic
Background		 129S/SvEv-Zbtb46tm1Kmm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb46tm1Kmm mutation (1 available); any Zbtb46 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:184205 )
N
• major cell populations in the lymphoid organs develop normally
abnormal dendritic cell physiology ( J:184205 )
• dendritic cells exhibit repressed alternate myeloid potential due to the failure down-regulate expression of granulocyte colony-stimulating factor and leukemia inhibitory factor receptors unlike wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory