Phenotypes associated with this allele

• Allele Symbol: Gpx3^tm1Jlos
• Allele Name: targeted mutation 1, Joseph Loscalzo
• Allele ID: MGI:5320577
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpx3^tm1Jlos/Gpx3^tm1Jlos	B6N.Cg-Gpx3^tm1Jlos	MGI:5320582
ht2	Gpx3^tm1Jlos/Gpx3^+	B6N.Cg-Gpx3^tm1Jlos	MGI:5320583

Genotype
MGI:5320582

hm1

• Allelic Composition: Gpx3^tm1Jlos/Gpx3^tm1Jlos
• Genetic Background: B6N.Cg-Gpx3^tm1Jlos

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:183744 )

• following ADP infusion

homeostasis/metabolism

abnormal blood homeostasis ( J:183744 )

• soluble plasma P-selectin levels are higher than in wild-type mice

• plasma cGMP levels are lower than in wild-type mice

increased platelet aggregation ( J:183744 )

• in response to the platelet agonist ADP

increased susceptibility to induced thrombosis ( J:183744 )

• following ADP infusion, mice exhibit enhanced platelet-dependent thrombosis compared with wild-type mice

decreased bleeding time ( J:183744 )

decreased susceptibility to ischemic brain injury ( J:183744 )

• following middle cerebral artery occlusion, mice exhibit decreased infarction size and neurological deficit score compared with wild-type mice

decreased cerebral infarct size ( J:183744 )

• following middle cerebral artery occlusion

cardiovascular system

abnormal blood vessel physiology ( J:183744 )

• blood vessels in methacholine-treated cremaster muscle exhibit less of a change in diameter compared with wild-type vessels

• following ADP infusion, mice exhibit a normalization of the highest increase in pulmonary artery pressure unlike wild-type mice

nervous system

decreased susceptibility to ischemic brain injury ( J:183744 )

• following middle cerebral artery occlusion, mice exhibit decreased infarction size and neurological deficit score compared with wild-type mice

decreased cerebral infarct size ( J:183744 )

• following middle cerebral artery occlusion

hematopoietic system

increased platelet aggregation ( J:183744 )

• in response to the platelet agonist ADP

Genotype
MGI:5320583

ht2

• Allelic Composition: Gpx3^tm1Jlos/Gpx3⁺
• Genetic Background: B6N.Cg-Gpx3^tm1Jlos

homeostasis/metabolism

increased platelet aggregation ( J:183744 )

• intermediate in response to the platelet agonist ADP

decreased bleeding time ( J:183744 )

• intermediate

hematopoietic system

increased platelet aggregation ( J:183744 )

• intermediate in response to the platelet agonist ADP