All Phenotypes Piwil2<tm1.1Doca> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Piwil2^tm1.1Doca
targeted mutation 1.1, Donal O'Carroll
MGI:5320635

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Piwil2^tm1.1Doca/Piwil2^tm1.1Doca	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J	MGI:5320672
cn2	Piwil2^tm1.1Doca/Piwil2^tm2.1Doca Tg(Stra8-icre)1Reb/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/NJ	MGI:5521299

Allelic Composition	Piwil2^tm1.1Doca/Piwil2^tm1.1Doca
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piwil2^tm1.1Doca mutation (1 available); any Piwil2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

arrest of male meiosis ( J:184034 )

abnormal male germ cell apoptosis ( J:184034 )

• 70% of mice exhibit a meiosis block in the early pachytene stage

• however, 30% of mice exhibit a slightly milder phenotype

testicular atrophy ( J:184034 )

male infertility ( J:184034 )

cellular

abnormal cell physiology ( J:184034 )

• mice exhibit defective piRNA biogenesis

arrest of male meiosis ( J:184034 )

abnormal male germ cell apoptosis ( J:184034 )

• 70% of mice exhibit a meiosis block in the early pachytene stage

• however, 30% of mice exhibit a slightly milder phenotype

abnormal DNA methylation ( J:184034 )

• mice exhibit defective CpG DNA methylation of L1 but not IAP elements in postnatal germ cells

endocrine/exocrine glands

testicular atrophy ( J:184034 )

Allelic Composition	Piwil2^tm1.1Doca/Piwil2^tm2.1Doca Tg(Stra8-icre)1Reb/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piwil2^tm1.1Doca mutation (1 available); any Piwil2 mutation (54 available)
Piwil2^tm2.1Doca mutation (1 available); any Piwil2 mutation (54 available)
Tg(Stra8-icre)1Reb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male germ cell apoptosis ( J:199259 )

• especially in meiotic cells

decreased testis weight ( J:199259 )

male infertility ( J:199259 )

cellular

abnormal cell physiology ( J:199259 )

• round spermatids fail to exhibit L1 transposon silencing unlike wild-type cells

abnormal male germ cell apoptosis ( J:199259 )

• especially in meiotic cells

endocrine/exocrine glands

decreased testis weight ( J:199259 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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