Phenotypes associated with this allele

• Allele Symbol: Frzb^tm1.1Fplu
• Allele Name: targeted mutation 1.1, Frank P Luyten
• Allele ID: MGI:5320664
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Frzb^tm1.1Fplu/Frzb^tm1.1Fplu	B6J.Cg-Frzb^tm1.1Fplu	MGI:5320666
hm2	Frzb^tm1.1Fplu/Frzb^tm1.1Fplu	involves: CD-1 * Swiss	MGI:5320665
hm3	Frzb^tm1.1Fplu/Frzb^tm1.1Fplu	Not Specified	MGI:5320885

Genotype
MGI:5320666

hm1

• Allelic Composition: Frzb^tm1.1Fplu/Frzb^tm1.1Fplu
• Genetic Background: B6J.Cg-Frzb^tm1.1Fplu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal skeleton physiology ( J:184281 )

• loss of sulfated proteoglycans from articular cartilage is increased 7 days after intraarticular papain injection, 21 days after collagenase injection, and 7 days after mBSA injection

• however, inflammatory and fibrotic changes are similar to controls and no increase in the incidence of spontaneous osteoarthritis of the knee is detected

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:184281 )

• loss of sulfated proteoglycans from articular cartilage is increased 7 days after intraarticular papain injection, 21 days after collagenase injection, and 7 days after mBSA injection

• however, inflammatory and fibrotic changes are similar to controls

Genotype
MGI:5320665

hm2

• Allelic Composition: Frzb^tm1.1Fplu/Frzb^tm1.1Fplu
• Genetic Background: involves: CD-1 * Swiss

skeleton

abnormal femur morphology ( J:184281 )

• increase in midfemoral bone surface area at 10 weeks of age in male and female mice

abnormal bone structure ( J:184281 )

increased bone mineral content ( J:184281 )

• higher cortical mineral content at 10, 16 and 20 weeks of age in male and female mice

increased bone mineral density ( J:184281 )

• higher cortical mineral density at 16 and 20 weeks of age in the tibia of male and female mice

increased compact bone thickness ( J:184281 )

• at 10, 16 and 20 weeks of age in male and female mice

abnormal skeleton physiology ( J:184281 )

abnormal bone remodeling ( J:184281 )

• enhanced anabolic effect (increase in periosteal bone volume) compared to wild-type controls

• at a strain rate of about 17,500 muepsilon/second a significant increase in bone volume is seen in ulnas from mutant mice but not from wild-type mice

increased bone strength ( J:184281 )

• similar loads result in lower strain indicating that the bones are stiffer

hematopoietic system

decreased hematocrit ( J:184281 )

limbs/digits/tail

abnormal femur morphology ( J:184281 )

• increase in midfemoral bone surface area at 10 weeks of age in male and female mice

Genotype
MGI:5320885

hm3

• Allelic Composition: Frzb^tm1.1Fplu/Frzb^tm1.1Fplu
• Genetic Background: Not Specified

nervous system

abnormal sensory neuron innervation pattern ( J:184011 )

• reduction in the innervation of TrkA+ and aquaporin 1+ sensory neurons in the dorsal horn

• reduced and disorganized sensory innervation of the dorsal horn by DiI labeled primary sensory axons

abnormal spinal cord dorsal horn morphology ( J:184011 )

• reduction in the innervation of TrkA+ and aquaporin 1+ sensory neurons in the dorsal horn

• reduced and disorganized sensory innervation of the dorsal horn by DiI labeled primary sensory axons