Phenotypes associated with this allele

• Allele Symbol: Igh^tm4.1Cog
• Allele Name: targeted mutation 4.1, Michel Cogne
• Allele ID: MGI:5320879
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm4.1Cog/Igh^tm4.1Cog	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5320886

Genotype
MGI:5320886

hm1

• Allelic Composition: Igh^tm4.1Cog/Igh^tm4.1Cog
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:184094 )

N • early B cell and plasma cell differentiation is normal

abnormal class switch recombination ( J:184094 )

• mice exhibit reduced IgM to IgA switching compared with wild-type mice

• however, LPS/TGF-beta induced switching is normal

decreased IgA level ( J:184094 )

• in the serum, jejunum fluid and plasma cells in the lamina propria

increased IgM level ( J:184094 )

• in digestive secretions

hematopoietic system

abnormal class switch recombination ( J:184094 )

• mice exhibit reduced IgM to IgA switching compared with wild-type mice

• however, LPS/TGF-beta induced switching is normal

decreased IgA level ( J:184094 )

• in the serum, jejunum fluid and plasma cells in the lamina propria

increased IgM level ( J:184094 )

• in digestive secretions