mortality/aging
• mice begin to die around 100 days and half of them have died by 500 days
|
renal/urinary system
albuminuria
(
J:184315
)
• as early as 10 days of age
• at 3 and 6 months
• however, renal disorder is suppressed by administration of Neu5Ac
|
• in the interstitium at 6 and 12 months
|
• pale and irregularly shaped
• however, renal disorder is suppressed by administration of Neu5Ac
|
• at 3 months
|
• flattened and fused at 4 months
|
• at 3 months
|
• at 3 months
• severe at 6 and 12 months
|
• at P8, 3 months, 6 months and 12 months
• however, renal disorder is suppressed by administration of Neu5Ac
|
• due to impaired maintenance
|
• at 3 months
|
pale kidney
(
J:184315
)
• at 6 and 12 months
• however, renal disorder is suppressed by administration of Neu5Ac
|
immune system
• in the interstitium at 6 and 12 months
|
homeostasis/metabolism
albuminuria
(
J:184315
)
• as early as 10 days of age
• at 3 and 6 months
• however, renal disorder is suppressed by administration of Neu5Ac
|