Phenotypes associated with this allele

• Allele Symbol: Tcf3^tm5.1Cmu
• Allele Name: targeted mutation 5.1, Cornelis Murre
• Allele ID: MGI:5424883
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tcf3^tm5.1Cmu/Tcf3^tm5.1Cmu	involves: 129S/SvEv * C57BL/6	MGI:5424886

Genotype
MGI:5424886

hm1

• Allelic Composition: Tcf3^tm5.1Cmu/Tcf3^tm5.1Cmu
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:183781 )

• mice are viable, breed with normal Mendelian frequencies, and do not exhibit gross abnormalities

immune system

immune system phenotype ( J:183781 )

N • bone marrow contains similar numbers of immature and mature B cells to controls

N • the mutated residue does not play a critical role in modulating Ig light chain VJ rearrangement, since normal numbers of Iglambda+ B cells are present in spleen

N • B cells derived from homozygous mice were not impaired in their ability to undergo class switch recombination