Phenotypes associated with this allele

• Allele Symbol: Vps41^tm1.1Ywd
• Allele Name: targeted mutation 1.1, Yoh Wada
• Allele ID: MGI:5425109
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vps41^tm1.1Ywd/Vps41^tm1.1Ywd	involves: 129S1/Sv * 129X1/SvJ	MGI:5425136

Genotype
MGI:5425136

hm1

• Allelic Composition: Vps41^tm1.1Ywd/Vps41^tm1.1Ywd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:184591 )

• embryonic lethality by E9

embryo

embryo phenotype ( J:184591 )

N • gross morphology is normal at E5.5

abnormal germ layer development ( J:184591 )

increased ectoderm apoptosis ( J:184591 )

• at E7.5

abnormal endoderm development ( J:184591 )

• visceral endoderm lacks apical vacuoles and accumulates electron dense spherical structures in the cytoplasm at E6.5

• accumulate eosinophilic granules at E5.5

• distally located cells remain columnar or cuboidal

abnormal mesoderm development ( J:184591 )

• impaired mesoderm growth at E8.5

abnormal embryonic tissue morphology ( J:184591 )

• embryonic region is smaller than in controls

abnormal egg cylinder morphology ( J:184591 )

• embryos remain as deformed egg cylinders at E8.5

abnormal lateral plate mesoderm morphology ( J:184591 )

• little if any lateral plate mesoderm

cellular

increased ectoderm apoptosis ( J:184591 )

• at E7.5

abnormal endocytosis ( J:184591 )

• defects in late stage endocytic pathway at E6.2