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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mns1tm1Jw
targeted mutation 1, Jeremy Wang
MGI:5425368
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mns1tm1Jw/Mns1tm1Jw involves: 129S4/SvJae * C57BL/6 MGI:5425369


Genotype
MGI:5425369
hm1
Allelic
Composition		 Mns1tm1Jw/Mns1tm1Jw
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mns1tm1Jw mutation (1 available); any Mns1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, incomplete penetrance ( J:183398 )
• fewer than expected homozygotes are found, lethality occurs sometime before weaning

reproductive system
abnormal outer dense fiber morphology ( J:183398 )
• outer dense fibers are completely disorganized
abnormal sperm axoneme morphology ( J:183398 )
• axonemal microtubules are completely disorganized
absent sperm fibrous sheath ( J:183398 )
• the sperm principal piece appears to be missing the fibrous sheath
kinked sperm flagellum ( J:183398 )
• most (98%) sperm have a very short crooked tail
short sperm flagellum ( J:183398 )
• most (98%) sperm have a very short crooked tail
oligozoospermia ( J:183398 )
• sperm count in the epididymides is reduced to 8% that of wild-type controls
abnormal spermatid morphology ( J:183398 )
• elongated spermatids appear to lack flagella
decreased testis weight ( J:183398 )
• at 8 weeks of age
abnormal epididymis morphology ( J:183398 )
• mostly filled with cell debris and contain few sperm

respiratory system
abnormal respiratory motile cilium morphology ( J:183398 )
• tracheal motile cilia lack some outer dynein arms and contain only about 4 of them per cross section compared to 9 per cross section in wild-type controls
left pulmonary isomerism ( J:183398 )
• randomized left-right patterning with 6 of 22 mice showing left-sided isomerism
lung situs inversus ( J:183398 )
• randomized left-right patterning with 8 of 22 mice showing situs inversus

nervous system
hydrocephaly ( J:183398 )
• starting at P4

growth/size/body
left pulmonary isomerism ( J:183398 )
• randomized left-right patterning with 6 of 22 mice showing left-sided isomerism
lung situs inversus ( J:183398 )
• randomized left-right patterning with 8 of 22 mice showing situs inversus

endocrine/exocrine glands
decreased testis weight ( J:183398 )
• at 8 weeks of age

cellular
abnormal respiratory motile cilium morphology ( J:183398 )
• tracheal motile cilia lack some outer dynein arms and contain only about 4 of them per cross section compared to 9 per cross section in wild-type controls
abnormal outer dense fiber morphology ( J:183398 )
• outer dense fibers are completely disorganized
abnormal sperm axoneme morphology ( J:183398 )
• axonemal microtubules are completely disorganized
absent sperm fibrous sheath ( J:183398 )
• the sperm principal piece appears to be missing the fibrous sheath
kinked sperm flagellum ( J:183398 )
• most (98%) sperm have a very short crooked tail
short sperm flagellum ( J:183398 )
• most (98%) sperm have a very short crooked tail
oligozoospermia ( J:183398 )
• sperm count in the epididymides is reduced to 8% that of wild-type controls
abnormal spermatid morphology ( J:183398 )
• elongated spermatids appear to lack flagella




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory