Allele Symbol Allele Name Allele ID |
Mtortm1.2Seq targeted mutation 1.2, Susan E Quaggin MGI:5425404 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• growth restriction observed starting around 4 weeks of age
• no overt phenotypes until after 3 weeks of age
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• protein/creatinine ratio is significantly increased at 3 weeks of age
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• protein/creatinine ratio is significantly increased at 3 weeks of age
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• distended Bowman's space at 5 weeks
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• numerous vacuolated podocytes at 4 weeks of age
• widespread vacuolation of podocytes at 5 weeks of age
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• focal effacement at 3 weeks of age but endothelium and glomerular basement membranes are preserved
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• areas of sclerosis at 4 weeks of age
• complete destruction of glomerular tuft at 5 weeks of age
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• proteinaceous casts found in tubules of 2-3 week old mice
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• autophagosomal vesicles accumulate in podocytes beginning at 2 weeks of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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