Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-cat,-Twist1)1Dbsp
• Allele Name: transgene insertion 1, Douglas B Spicer
• Allele ID: MGI:5425605
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(CAG-cat,-Twist1)1Dbsp/0 Tg(Col2a1-cre)1Bhr/0	involves: C57BL/6 * FVB * SJL	MGI:5487798

Genotype
MGI:5487798

cn1

• Allelic Composition: Tg(CAG-cat,-Twist1)1Dbsp/0; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: C57BL/6 * FVB * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:178268 )

• runted phenotype observed at two weeks of age

decreased body weight ( J:178268 )

• 36-41% reduction in body mass as compared to control

limbs/digits/tail

short limbs ( J:178268 )

• first observed at two weeks of age

• at 8 weeks of age femur and tibia are approximate 14% and 13%, respectively, shorter than controls

skeleton

abnormal long bone epiphyseal plate morphology ( J:178268 )

abnormal long bone epiphyseal plate proliferative zone ( J:178268 )

• tibial growth plates exhibit disorderly columnar arrays of proliferating chondrocytes and acellular regions in the proliferating zone

• atypical vascular invasion and focal regions of bony deposition disrupt contiguous columns of chrondocytes

increased width of hypertrophic chondrocyte zone ( J:178268 )

• width of the tibial growth plate hypertrophic zone is enlarged in four and eight week old mice

decreased trabecular bone volume ( J:178268 )

• decrease in trabecular bone volume fraction is observed in transgenic mice at 4 and 8 weeks

decreased bone trabecula number ( J:178268 )

• reduced trabecular number and increased trabecular spacing

decreased trabecular bone thickness ( J:178268 )

abnormal ossification involved in bone maturation ( J:178268 )

• proportion of cartilage to bone is higher in 2 and 4 week old transgenic mice as compared to controls